ITPKA
UniProt ID: P23677
Entrez ID: 3706
Protein name: Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:15350214, ECO:0000269|PubMed:1847047}....
FUNCTION: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:15350214, ECO:0000269|PubMed:1847047}.
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GO - Biological processes (BP):
actin cytoskeleton organization [GO:0030036]; dendritic spine maintenance [GO:0097062]; inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of dendritic spine morphogenesi...
actin cytoskeleton organization [GO:0030036]; dendritic spine maintenance [GO:0097062]; inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of dendritic spine morphogenesis [GO:0061003]; regulation of synaptic plasticity [GO:0048167]; signal transduction [GO:0007165]
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GO - Molecular function (MF):
ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]; inositol hexakisphosphate kinase activity [GO:0000828]; kinase activity [GO:0016301]; small GTPase binding [GO:0031267]...
ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]; inositol hexakisphosphate kinase activity [GO:0000828]; kinase activity [GO:0016301]; small GTPase binding [GO:0031267]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleus [GO:0005634]...
cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleus [GO:0005634]
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ITPKA
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Kaplan plot for ITPKA in
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*NOTE: the Kaplan plots were collected from OncoLnc