DegronMD

Uniprot ID: P23677

Source protein: Inositol-trisphosphate 3-kinase A

Source gene: ITPKA

Class: DEG_SIAH_1

Location: 73:81

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9685

ASA_SCORE: 72.2111

COIL: 0.886

CONS_SCORE: 0.3345

DSS_SCORE: 0.6718

HELIX: 0.0116

FCONS_SCORE: 0.9917

RIG_SCORE: 0.6383

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G69V	DO228039	EOPC	ICGC	APPAPVIPQ	DEG_SIAH_1	0.2222
p.P75T	DO233272	GACA	ICGC	APPAPVIPQ	DEG_SIAH_1	0.5919
p.P67S	DO51124	PRAD	ICGC	APPAPVIPQ	DEG_SIAH_1	0.1667
p.E87D	SIDM01307	Colorectal Carcinoma	GDSC	APPAPVIPQ	DEG_SIAH_1	0.1667
p.D90G	ACH-000999	Colon/Colorectal Cancer	CCLE	APPAPVIPQ	DEG_SIAH_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23677	Inositol-trisphosphate 3-kinase A	DEG_SIAH_1	73:81	APPAPVIPQ	SIAH1,SIAH2,SIAH3	0.9685	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons