DegronMD - P24001(IL32)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A128S	TCGA-92-8065	LUSC	TCGA	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1111
p.R118W	TCGA-A5-A0G2	UCEC	TCGA	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.8634
p.R118W	TCGA-HU-A4G9	STAD	TCGA	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.8634
p.R118W	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.8634
p.G125R	TCGA-AA-A01T	COAD	TCGA	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1944
p.R110I	TCGA-B5-A1MR	UCEC	TCGA	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.25
p.F104S	TCGA-EE-A17X	SKCM	TCGA	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.0833
p.A114V	TCGA-FR-A3R1	SKCM	TCGA	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.6936
p.M109I	TCGA-FW-A3R5	SKCM	TCGA	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222
p.M109I	ACH-000993	Endometrial/Uterine Cancer	CCLE	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222
p.A105V	DO9530	COAD	ICGC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1111
p.G130S	DO51566	KIRP	ICGC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.0556
p.D124Y	DO229038	LICA	ICGC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222
p.E120Q	DO27572	LUSC	ICGC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.6744
p.L126S	DO232761	PBCA	ICGC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1667
p.A106S	DO220011	SARC	ICGC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1389
p.P113S	DO229467	SKCA	ICGC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.6752
p.R127Q	DO223286	UCEC	ICGC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1389
p.R127W	DO41871	UCEC	ICGC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1389
p.R127W	ACH-001127	Leukemia	CCLE	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1389
p.R127W	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1389
p.R123I	DO41361	UCEC	ICGC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.25
p.T116I	ACH-000478	Liver Cancer	CCLE	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.8189
p.T116I	SNU-387	liver	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.8189
p.V126I	ACH-000525	Lung Cancer	CCLE	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1667
p.V126I	NCI-H2171	lung	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1667
p.E123A	Hep_3B2_1-7	NS	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.25
p.E122A	Hep_3B2_1-7	NS	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2778
p.E112A	Hep_3B2_1-7	NS	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.3056
p.H124Y	DND-41	haematopoietic and lymphoid tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222
p.R105W	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1111
p.V117I	NCI-H2171	lung	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.7076
p.L119M	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.5999
p.V106I	NCI-H2171	lung	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1389
p.C113R	EN	endometrium	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.8301
p.H114Y	DND-41	haematopoietic and lymphoid tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.7229
p.H115Y	DND-41	haematopoietic and lymphoid tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.7229
p.T107I	SNU-387	liver	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation blocking phosphorylation signal	0.6111
p.H104Y	DND-41	haematopoietic and lymphoid tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.0833
p.V116I	NCI-H2171	lung	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.7076

Kaplan plot for IL32 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IL32

UniProt ID: P24001

Entrez ID: 9235

Protein name: Interleukin-32 (IL-32) (Natural killer cells protein 4) (Tumor necrosis factor alpha-inducing factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IL32 in