DegronMD

Uniprot ID: P24001

Source protein: Interleukin-32

Source gene: IL32

Class: DEG_SCF_FBW7_2

Location: 113:120

E3 ligase: FBXW7

DEGRON score: 0.9553

ASA_SCORE: 69.975

COIL: 0.5194

CONS_SCORE: 1

DSS_SCORE: 0.5152

HELIX: 0.4488

FCONS_SCORE: 1

RIG_SCORE: 0.7766

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A128S	TCGA-92-8065	LUSC	TCGA	PELTPLLE	DEG_SCF_FBW7_2	0.1111
p.R118W	TCGA-A5-A0G2	UCEC	TCGA	PELTPLLE	DEG_SCF_FBW7_2	0.8634
p.R118W	TCGA-HU-A4G9	STAD	TCGA	PELTPLLE	DEG_SCF_FBW7_2	0.8634
p.R118W	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.8634
p.G125R	TCGA-AA-A01T	COAD	TCGA	PELTPLLE	DEG_SCF_FBW7_2	0.1944
p.R110I	TCGA-B5-A1MR	UCEC	TCGA	PELTPLLE	DEG_SCF_FBW7_2	0.25
p.F104S	TCGA-EE-A17X	SKCM	TCGA	PELTPLLE	DEG_SCF_FBW7_2	0.0833
p.A114V	TCGA-FR-A3R1	SKCM	TCGA	PELTPLLE	DEG_SCF_FBW7_2	0.6936
p.M109I	TCGA-FW-A3R5	SKCM	TCGA	PELTPLLE	DEG_SCF_FBW7_2	0.2222
p.M109I	ACH-000993	Endometrial/Uterine Cancer	CCLE	PELTPLLE	DEG_SCF_FBW7_2	0.2222
p.A105V	DO9530	COAD	ICGC	PELTPLLE	DEG_SCF_FBW7_2	0.1111
p.G130S	DO51566	KIRP	ICGC	PELTPLLE	DEG_SCF_FBW7_2	0.0556
p.D124Y	DO229038	LICA	ICGC	PELTPLLE	DEG_SCF_FBW7_2	0.2222
p.E120Q	DO27572	LUSC	ICGC	PELTPLLE	DEG_SCF_FBW7_2	0.6744
p.L126S	DO232761	PBCA	ICGC	PELTPLLE	DEG_SCF_FBW7_2	0.1667
p.A106S	DO220011	SARC	ICGC	PELTPLLE	DEG_SCF_FBW7_2	0.1389
p.P113S	DO229467	SKCA	ICGC	PELTPLLE	DEG_SCF_FBW7_2	0.6752
p.R127Q	DO223286	UCEC	ICGC	PELTPLLE	DEG_SCF_FBW7_2	0.1389
p.R127W	DO41871	UCEC	ICGC	PELTPLLE	DEG_SCF_FBW7_2	0.1389
p.R127W	ACH-001127	Leukemia	CCLE	PELTPLLE	DEG_SCF_FBW7_2	0.1389
p.R127W	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.1389
p.R123I	DO41361	UCEC	ICGC	PELTPLLE	DEG_SCF_FBW7_2	0.25
p.T116I	ACH-000478	Liver Cancer	CCLE	PELTPLLE	DEG_SCF_FBW7_2	0.8189
p.T116I	SNU-387	liver	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.8189
p.V126I	ACH-000525	Lung Cancer	CCLE	PELTPLLE	DEG_SCF_FBW7_2	0.1667
p.V126I	NCI-H2171	lung	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.1667
p.E123A	Hep_3B2_1-7	NS	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.25
p.E122A	Hep_3B2_1-7	NS	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.2778
p.E112A	Hep_3B2_1-7	NS	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.3056
p.H124Y	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.2222
p.R105W	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.1111
p.V117I	NCI-H2171	lung	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.7076
p.L119M	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.5999
p.V106I	NCI-H2171	lung	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.1389
p.C113R	EN	endometrium	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.8301
p.H114Y	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.7229
p.H115Y	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.7229
p.T107I	SNU-387	liver	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.6111
p.H104Y	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.0833
p.V116I	NCI-H2171	lung	COSMIC	PELTPLLE	DEG_SCF_FBW7_2	0.7076

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PELTPLLE

Degron related mutations and impact score

Drug responses associated with IL32 mutations

All proteins holding degron of PELTPLLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24001	Interleukin-32	DEG_SCF_FBW7_2	113:120	PELTPLLE	FBXW7	0.9553	More...