DegronMD - P24043(LAMA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G2749S	TCGA-14-0781	GBM	TCGA	PTPTPVLT	DEG_SCF_FBW7_1	2740:2747	Mutation rewiring degron network	0.2778
p.G2749S	DO13905	GBM	ICGC	PTPTPVLT	DEG_SCF_FBW7_1	2740:2747	Mutation rewiring degron network	0.2778
p.E2754G	DO225330	BRCA	ICGC	PTPTPVLT	DEG_SCF_FBW7_1	2740:2747	Mutation rewiring degron network	0.1389
p.T2747A	DO229542	UTCA	ICGC	PTPTPVLT	DEG_SCF_FBW7_1	2740:2747	Mutation altering degron motif	0.7139
p.P2731S	SIDM00660	Colorectal Carcinoma	GDSC	PTPTPVLT	DEG_SCF_FBW7_1	2740:2747	Mutation rewiring degron network	0.0833
p.P2731S	ACH-000985	Colon/Colorectal Cancer	CCLE	PTPTPVLT	DEG_SCF_FBW7_1	2740:2747	Mutation rewiring degron network	0.0833
p.P2731S	LS-411N	large intestine	COSMIC	PTPTPVLT	DEG_SCF_FBW7_1	2740:2747	Mutation rewiring degron network	0.0833
p.T2743I	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PTPTPVLT	DEG_SCF_FBW7_1	2740:2747	Mutation altering degron motif	0.7078
p.T2743I	ACH-001737	Leukemia	CCLE	PTPTPVLT	DEG_SCF_FBW7_1	2740:2747	Mutation altering degron motif	0.7078
p.T2743I	ACH-002222	Leukemia	CCLE	PTPTPVLT	DEG_SCF_FBW7_1	2740:2747	Mutation altering degron motif	0.7078
p.T2743I	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PTPTPVLT	DEG_SCF_FBW7_1	2740:2747	Mutation altering degron motif	0.7078
p.P2730S	LS-411N	large intestine	COSMIC	PTPTPVLT	DEG_SCF_FBW7_1	2740:2747	Mutation rewiring degron network	0.0556
p.T2739I	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PTPTPVLT	DEG_SCF_FBW7_1	2740:2747	Mutation rewiring degron network	0.3056
p.T2742I	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PTPTPVLT	DEG_SCF_FBW7_1	2740:2747	Mutation altering degron motif	0.7078

Kaplan plot for LAMA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LAMA2

UniProt ID: P24043

Entrez ID: 3908

Protein name: Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LAMA2 in