DegronMD

Uniprot ID: P24043

Source protein: Laminin subunit alpha-2

Source gene: LAMA2

Class: DEG_SCF_FBW7_1

Location: 2740:2747

E3 ligase: FBXW7

DEGRON score: 0.9454

ASA_SCORE: 88.6375

COIL: 0.9344

CONS_SCORE: 0.2317

DSS_SCORE: 0.5934

HELIX: 0.0188

FCONS_SCORE: 0.8107

RIG_SCORE: 0.6897

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2749S	TCGA-14-0781	GBM	TCGA	PTPTPVLT	DEG_SCF_FBW7_1	0.2778
p.G2749S	DO13905	GBM	ICGC	PTPTPVLT	DEG_SCF_FBW7_1	0.2778
p.E2754G	DO225330	BRCA	ICGC	PTPTPVLT	DEG_SCF_FBW7_1	0.1389
p.T2747A	DO229542	UTCA	ICGC	PTPTPVLT	DEG_SCF_FBW7_1	0.7139
p.P2731S	SIDM00660	Colorectal Carcinoma	GDSC	PTPTPVLT	DEG_SCF_FBW7_1	0.0833
p.P2731S	ACH-000985	Colon/Colorectal Cancer	CCLE	PTPTPVLT	DEG_SCF_FBW7_1	0.0833
p.P2731S	LS-411N	large_intestine	COSMIC	PTPTPVLT	DEG_SCF_FBW7_1	0.0833
p.T2743I	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PTPTPVLT	DEG_SCF_FBW7_1	0.7078
p.T2743I	ACH-001737	Leukemia	CCLE	PTPTPVLT	DEG_SCF_FBW7_1	0.7078
p.T2743I	ACH-002222	Leukemia	CCLE	PTPTPVLT	DEG_SCF_FBW7_1	0.7078
p.T2743I	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPTPVLT	DEG_SCF_FBW7_1	0.7078
p.P2730S	LS-411N	large_intestine	COSMIC	PTPTPVLT	DEG_SCF_FBW7_1	0.0556
p.T2739I	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPTPVLT	DEG_SCF_FBW7_1	0.3056
p.T2742I	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPTPVLT	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24043	Laminin subunit alpha-2	DEG_SCF_FBW7_1	2740:2747	PTPTPVLT	FBXW7	0.9454	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons