DegronMD - P24468(NR2F2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G65S	TCGA-A5-A1OF	UCEC	TCGA	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation rewiring degron network	0.0556
p.G65S	DO42568	UCEC	ICGC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation rewiring degron network	0.0556
p.P52L	DO522	BLCA	ICGC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation altering degron motif	0.7582
p.P52L	SIDM00877	Breast Carcinoma	GDSC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation altering degron motif	0.7582
p.R65K	DO48990	CESC	ICGC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation rewiring degron network	0.0556
p.A63D	DO234463	ESAD	ICGC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation rewiring degron network	0.1111
p.N51I	DO233649	GACA	ICGC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation altering degron motif	0.728
p.G55S	DO233855	GACA	ICGC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation altering degron motif	0.6993
p.A63S	DO233920	GACA	ICGC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation rewiring degron network	0.1111
p.A63S	EN	endometrium	COSMIC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation rewiring degron network	0.1111
p.E61V	DO26689	LUSC	ICGC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation rewiring degron network	0.1667
p.G47C	DO27453	LUSC	ICGC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation rewiring degron network	0.3056
p.M48I	DO38743	STAD	ICGC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation altering degron motif	0.7618
p.A49V	DO229275	THCA	ICGC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation altering degron motif	0.5825
p.Q41H	DO229221	THCA	ICGC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation rewiring degron network	0.1389
p.A49S	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation altering degron motif	0.6477
p.A49S	ACH-000858	Lung Cancer	CCLE	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation altering degron motif	0.6477
p.G61D	ACH-001991	Primary	CCLE	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation rewiring degron network	0.1667
p.S45G	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation rewiring degron network	0.25
p.E57K	PCI-30	upper aerodigestive tract	COSMIC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation rewiring degron network	0.2778
p.Y48N	DG-75	haematopoietic and lymphoid tissue	COSMIC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation altering degron motif	0.7059
p.S43P	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation rewiring degron network	0.1944
p.S65G	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PASTPAQT	DEG_SCF_FBW7_1	48:55	Mutation rewiring degron network	0.0556

Kaplan plot for NR2F2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NR2F2

UniProt ID: P24468

Entrez ID: 7026

Protein name: COUP transcription factor 2 (COUP-TF2) (Apolipoprotein A-I regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NR2F2 in