DegronMD

Uniprot ID: P24468

Source protein: COUP transcription factor 2

Source gene: NR2F2

Class: DEG_SCF_FBW7_1

Location: 48:55

E3 ligase: FBXW7

DEGRON score: 0.9517

ASA_SCORE: 78.0375

COIL: 0.8049

CONS_SCORE: 0.4554

DSS_SCORE: 0.8817

HELIX: 0.1656

FCONS_SCORE: 0.9709

RIG_SCORE: 0.5501

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G65S	TCGA-A5-A1OF	UCEC	TCGA	PASTPAQT	DEG_SCF_FBW7_1	0.0556
p.G65S	DO42568	UCEC	ICGC	PASTPAQT	DEG_SCF_FBW7_1	0.0556
p.P52L	DO522	BLCA	ICGC	PASTPAQT	DEG_SCF_FBW7_1	0.7582
p.P52L	SIDM00877	Breast Carcinoma	GDSC	PASTPAQT	DEG_SCF_FBW7_1	0.7582
p.R65K	DO48990	CESC	ICGC	PASTPAQT	DEG_SCF_FBW7_1	0.0556
p.A63D	DO234463	ESAD	ICGC	PASTPAQT	DEG_SCF_FBW7_1	0.1111
p.N51I	DO233649	GACA	ICGC	PASTPAQT	DEG_SCF_FBW7_1	0.728
p.G55S	DO233855	GACA	ICGC	PASTPAQT	DEG_SCF_FBW7_1	0.6993
p.A63S	DO233920	GACA	ICGC	PASTPAQT	DEG_SCF_FBW7_1	0.1111
p.A63S	EN	endometrium	COSMIC	PASTPAQT	DEG_SCF_FBW7_1	0.1111
p.E61V	DO26689	LUSC	ICGC	PASTPAQT	DEG_SCF_FBW7_1	0.1667
p.G47C	DO27453	LUSC	ICGC	PASTPAQT	DEG_SCF_FBW7_1	0.3056
p.M48I	DO38743	STAD	ICGC	PASTPAQT	DEG_SCF_FBW7_1	0.7618
p.A49V	DO229275	THCA	ICGC	PASTPAQT	DEG_SCF_FBW7_1	0.5825
p.Q41H	DO229221	THCA	ICGC	PASTPAQT	DEG_SCF_FBW7_1	0.1389
p.A49S	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PASTPAQT	DEG_SCF_FBW7_1	0.6477
p.A49S	ACH-000858	Lung Cancer	CCLE	PASTPAQT	DEG_SCF_FBW7_1	0.6477
p.G61D	ACH-001991	Primary	CCLE	PASTPAQT	DEG_SCF_FBW7_1	0.1667
p.S45G	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PASTPAQT	DEG_SCF_FBW7_1	0.25
p.E57K	PCI-30	upper_aerodigestive_tract	COSMIC	PASTPAQT	DEG_SCF_FBW7_1	0.2778
p.Y48N	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PASTPAQT	DEG_SCF_FBW7_1	0.7059
p.S43P	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PASTPAQT	DEG_SCF_FBW7_1	0.1944
p.S65G	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PASTPAQT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24468	COUP transcription factor 2	DEG_SCF_FBW7_1	48:55	PASTPAQT	FBXW7	0.9517	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons