DegronMD - P25685(DNAJB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H166Q	TCGA-55-8089	LUAD	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2778
p.V164A	TCGA-66-2763	LUSC	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2222
p.I185V	TCGA-CN-5359	HNSC	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0833
p.L172I	TCGA-D8-A1JC	BRCA	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.7174
p.D167H	TCGA-J1-A4AH	LUSC	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.3056
p.A158D	DO229025	LICA	ICGC	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation substituting flanking lysine	0.1667
p.R163W	DO42384	UCEC	ICGC	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1944
p.T180M	DO41644	UCEC	ICGC	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation blocking phosphorylation signal	0.6667
p.T180M	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation blocking phosphorylation signal	0.6667
p.P162T	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1667
p.P162T	ACH-000929	Lung Cancer	CCLE	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1667
p.P162T	NCI-H2110	lung	COSMIC	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1667
p.K181E	SIDM00875	Breast Carcinoma	GDSC	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation blocking ubiquitination signal	0.6389
p.K181E	ACH-000624	Breast Cancer	CCLE	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation blocking ubiquitination signal	0.6389
p.K181E	HCC1806	breast	COSMIC	LRVSLEEIY	DEG_APCC_DBOX_1	168:176	Mutation blocking ubiquitination signal	0.6389

Kaplan plot for DNAJB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAJB1

UniProt ID: P25685

Entrez ID: 3337

Protein name: DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAJB1 in