DegronMD

Uniprot ID: P25685

Source protein: DnaJ homolog subfamily B member 1

Source gene: DNAJB1

Class: DEG_APCC_DBOX_1

Location: 168:176

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9784

ASA_SCORE: 60.9333

COIL: 0.2357

CONS_SCORE: 0.5688

DSS_SCORE: 0.4368

HELIX: 0.0166

FCONS_SCORE: 1.2838

RIG_SCORE: 0.7872

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H166Q	TCGA-55-8089	LUAD	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	0.2778
p.V164A	TCGA-66-2763	LUSC	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	0.2222
p.I185V	TCGA-CN-5359	HNSC	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	0.0833
p.L172I	TCGA-D8-A1JC	BRCA	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	0.7174
p.D167H	TCGA-J1-A4AH	LUSC	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	0.3056
p.A158D	DO229025	LICA	ICGC	LRVSLEEIY	DEG_APCC_DBOX_1	0.1667
p.R163W	DO42384	UCEC	ICGC	LRVSLEEIY	DEG_APCC_DBOX_1	0.1944
p.T180M	DO41644	UCEC	ICGC	LRVSLEEIY	DEG_APCC_DBOX_1	0.6667
p.T180M	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LRVSLEEIY	DEG_APCC_DBOX_1	0.6667
p.P162T	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	LRVSLEEIY	DEG_APCC_DBOX_1	0.1667
p.P162T	ACH-000929	Lung Cancer	CCLE	LRVSLEEIY	DEG_APCC_DBOX_1	0.1667
p.P162T	NCI-H2110	lung	COSMIC	LRVSLEEIY	DEG_APCC_DBOX_1	0.1667
p.K181E	SIDM00875	Breast Carcinoma	GDSC	LRVSLEEIY	DEG_APCC_DBOX_1	0.6389
p.K181E	ACH-000624	Breast Cancer	CCLE	LRVSLEEIY	DEG_APCC_DBOX_1	0.6389
p.K181E	HCC1806	breast	COSMIC	LRVSLEEIY	DEG_APCC_DBOX_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25685	DnaJ homolog subfamily B member 1	DEG_APCC_DBOX_1	168:176	LRVSLEEIY	APC,CDC20,FZR1	0.9784	More...
Q9UDY4	DnaJ homolog subfamily B member 4	DEG_APCC_DBOX_1	164:172	LRVSLEEIY	APC,CDC20,FZR1	0.5098	More...
O75953	DnaJ homolog subfamily B member 5	DEG_APCC_DBOX_1	175:183	LRVSLEEIY	APC,CDC20,FZR1	0.6928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons