DegronMD

Uniprot ID: Q9UDY4

Source protein: DnaJ homolog subfamily B member 4

Source gene: DNAJB4

Class: DEG_APCC_DBOX_1

Location: 164:172

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5098

ASA_SCORE: 53.7667

COIL: 0.2478

CONS_SCORE: 0.6613

DSS_SCORE: 0.3044

HELIX: 0.3646

FCONS_SCORE: 1.2708

RIG_SCORE: 0.8206

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S182Y	TCGA-ND-A4WC	UCS	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	0.0556
p.S167L	TCGA-P3-A5QF	HNSC	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	0.7667
p.S167L	DO44439	HNSC	ICGC	LRVSLEEIY	DEG_APCC_DBOX_1	0.7667
p.R178W	DO220823	BRCA	ICGC	LRVSLEEIY	DEG_APCC_DBOX_1	0.1667
p.I161S	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	LRVSLEEIY	DEG_APCC_DBOX_1	0.25
p.I161S	ACH-000647	Esophageal Cancer	CCLE	LRVSLEEIY	DEG_APCC_DBOX_1	0.25
p.I161S	TE-1	oesophagus	COSMIC	LRVSLEEIY	DEG_APCC_DBOX_1	0.25
p.R178L	ACH-001645	Skin Cancer	CCLE	LRVSLEEIY	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25685	DnaJ homolog subfamily B member 1	DEG_APCC_DBOX_1	168:176	LRVSLEEIY	APC,CDC20,FZR1	0.9784	More...
Q9UDY4	DnaJ homolog subfamily B member 4	DEG_APCC_DBOX_1	164:172	LRVSLEEIY	APC,CDC20,FZR1	0.5098	More...
O75953	DnaJ homolog subfamily B member 5	DEG_APCC_DBOX_1	175:183	LRVSLEEIY	APC,CDC20,FZR1	0.6928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons