DegronMD

Uniprot ID: O75953

Source protein: DnaJ homolog subfamily B member 5

Source gene: DNAJB5

Class: DEG_APCC_DBOX_1

Location: 175:183

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6928

ASA_SCORE: 75.8333

COIL: 0.4304

CONS_SCORE: 0.6387

DSS_SCORE: 0.3968

HELIX: 0.2122

FCONS_SCORE: 1.2772

RIG_SCORE: 0.7776

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E183K	TCGA-AA-A01T	COAD	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	0.7022
p.G189S	TCGA-AG-3742	READ	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	0.1667
p.L186P	TCGA-AP-A1DK	UCEC	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	0.25
p.E183Q	TCGA-CG-4437	STAD	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	0.6744
p.G189R	TCGA-EB-A3Y7	SKCM	TCGA	LRVSLEEIY	DEG_APCC_DBOX_1	0.1667
p.E169D	DO227976	COCA	ICGC	LRVSLEEIY	DEG_APCC_DBOX_1	0.1667
p.R176L	DO229008	LICA	ICGC	LRVSLEEIY	DEG_APCC_DBOX_1	0.8428
p.G190S	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LRVSLEEIY	DEG_APCC_DBOX_1	0.1389
p.G190S	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LRVSLEEIY	DEG_APCC_DBOX_1	0.1389
p.G190S	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LRVSLEEIY	DEG_APCC_DBOX_1	0.1389
p.S170I	SIDM00980	Gastric Carcinoma	GDSC	LRVSLEEIY	DEG_APCC_DBOX_1	0.1944
p.S170I	23132-87	stomach	COSMIC	LRVSLEEIY	DEG_APCC_DBOX_1	0.1944
p.S177P	MFE-319	endometrium	COSMIC	LRVSLEEIY	DEG_APCC_DBOX_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25685	DnaJ homolog subfamily B member 1	DEG_APCC_DBOX_1	168:176	LRVSLEEIY	APC,CDC20,FZR1	0.9784	More...
Q9UDY4	DnaJ homolog subfamily B member 4	DEG_APCC_DBOX_1	164:172	LRVSLEEIY	APC,CDC20,FZR1	0.5098	More...
O75953	DnaJ homolog subfamily B member 5	DEG_APCC_DBOX_1	175:183	LRVSLEEIY	APC,CDC20,FZR1	0.6928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons