DegronMD - P25786(PSMA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D233N	TCGA-90-A4EE	LUSC	TCGA	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation rewiring degron network	0.1389
p.D233N	TCGA-FD-A3SS	BLCA	TCGA	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation rewiring degron network	0.1389
p.D233G	TCGA-BG-A0MK	UCEC	TCGA	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation rewiring degron network	0.1389
p.T228A	TCGA-CG-5726	STAD	TCGA	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation rewiring degron network	0.2778
p.D224Y	TCGA-DU-6392	LGG	TCGA	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation altering degron motif	0.7325
p.E227Q	DO219052	BLCA	ICGC	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation rewiring degron network	0.3056
p.A222V	DO222762	COCA	ICGC	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation altering degron motif	0.6936
p.A229S	DO14204	HNSC	ICGC	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation rewiring degron network	0.25
p.A229V	DO14204	HNSC	ICGC	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation rewiring degron network	0.25
p.P221T	DO229029	LICA	ICGC	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation altering degron motif	0.7031
p.L211V	DO50848	LIRI	ICGC	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation blocking phosphorylation signal	0.5
p.M236V	DO24364	LUAD	ICGC	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation rewiring degron network	0.0556
p.M236V	HEC-1	endometrium	COSMIC	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation rewiring degron network	0.0556
p.R214T	DO219163	LUSC	ICGC	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation rewiring degron network	0.1389
p.P224L	DO37471	SKCM	ICGC	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation altering degron motif	0.7582
p.Q220R	DO41999	UCEC	ICGC	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation rewiring degron network	0.3056
p.D226G	SNU-1040	large intestine	COSMIC	FTIYDD	LIG_APCC_ABBA_1	221:226	Mutation altering degron motif	0.7198

Kaplan plot for PSMA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSMA1

UniProt ID: P25786

Entrez ID: 5682

Protein name: Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSMA1 in