DegronMD

Uniprot ID: P25786

Source protein: Proteasome subunit alpha type-1

Source gene: PSMA1

Class: LIG_APCC_ABBA_1

Location: 221:226

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.687

ASA_SCORE: 48.7

COIL: 0.3423

CONS_SCORE: 0.6251

DSS_SCORE: 0.3344

HELIX: 0.1575

FCONS_SCORE: 1.0355

RIG_SCORE: 0.8538

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D233N	TCGA-90-A4EE	LUSC	TCGA	FTIYDD	LIG_APCC_ABBA_1	0.1389
p.D233N	TCGA-FD-A3SS	BLCA	TCGA	FTIYDD	LIG_APCC_ABBA_1	0.1389
p.D233G	TCGA-BG-A0MK	UCEC	TCGA	FTIYDD	LIG_APCC_ABBA_1	0.1389
p.T228A	TCGA-CG-5726	STAD	TCGA	FTIYDD	LIG_APCC_ABBA_1	0.2778
p.D224Y	TCGA-DU-6392	LGG	TCGA	FTIYDD	LIG_APCC_ABBA_1	0.7325
p.E227Q	DO219052	BLCA	ICGC	FTIYDD	LIG_APCC_ABBA_1	0.3056
p.A222V	DO222762	COCA	ICGC	FTIYDD	LIG_APCC_ABBA_1	0.6936
p.A229S	DO14204	HNSC	ICGC	FTIYDD	LIG_APCC_ABBA_1	0.25
p.A229V	DO14204	HNSC	ICGC	FTIYDD	LIG_APCC_ABBA_1	0.25
p.P221T	DO229029	LICA	ICGC	FTIYDD	LIG_APCC_ABBA_1	0.7031
p.L211V	DO50848	LIRI	ICGC	FTIYDD	LIG_APCC_ABBA_1	0.5
p.M236V	DO24364	LUAD	ICGC	FTIYDD	LIG_APCC_ABBA_1	0.0556
p.M236V	HEC-1	endometrium	COSMIC	FTIYDD	LIG_APCC_ABBA_1	0.0556
p.R214T	DO219163	LUSC	ICGC	FTIYDD	LIG_APCC_ABBA_1	0.1389
p.P224L	DO37471	SKCM	ICGC	FTIYDD	LIG_APCC_ABBA_1	0.7582
p.Q220R	DO41999	UCEC	ICGC	FTIYDD	LIG_APCC_ABBA_1	0.3056
p.D226G	SNU-1040	large_intestine	COSMIC	FTIYDD	LIG_APCC_ABBA_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25786	Proteasome subunit alpha type-1	LIG_APCC_ABBA_1	221:226	FTIYDD	APC,CDC20,FZR1	0.687	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons