DegronMD - P26358(DNMT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R136H	TCGA-A5-A0G2	UCEC	TCGA	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.7133
p.R136H	TCGA-AG-A02N	READ	TCGA	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.7133
p.R136H	DO37146	READ	ICGC	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.7133
p.R136H	DO41235	UCEC	ICGC	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.7133
p.P138L	DO233898	GACA	ICGC	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.7582
p.P135T	DO228971	LICA	ICGC	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.7031
p.R139K	DO50970	LICA	ICGC	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.6126
p.R139S	DO23216	LINC	ICGC	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.6316
p.A147T	DO45223	LIRI	ICGC	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation rewiring degron network	0.1667
p.T137M	SIDM02059	Colorectal Carcinoma	GDSC	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.8534
p.P128T	SIDM00270	Head and Neck Carcinoma	GDSC	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation rewiring degron network	0.1389
p.N126H	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation rewiring degron network	0.0833
p.N126H	ACH-000843	Lung Cancer	CCLE	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation rewiring degron network	0.0833
p.N126H	HARA	lung	COSMIC	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation rewiring degron network	0.0833
p.L132P	SIDM00014	Colorectal Carcinoma	GDSC	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation rewiring degron network	0.25
p.L132P	LIM1215	large intestine	COSMIC	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation rewiring degron network	0.25
p.T137R	SIDM01434	Hepatocellular Carcinoma	GDSC	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.8987
p.T137R	ACH-000316	Liver Cancer	CCLE	PRTPRRS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.8987

Kaplan plot for DNMT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNMT1

UniProt ID: P26358

Entrez ID: 1786

Protein name: DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNMT1 in