DegronMD

Uniprot ID: P26358

Source protein: DNA

Source gene: DNMT1

Class: DEG_SCF_FBW7_1

Location: 135:141

E3 ligase: FBXW7

DEGRON score: 0.9274

ASA_SCORE: 113.1857

COIL: 0.9506

CONS_SCORE: 0.314

DSS_SCORE: 0.8636

HELIX: 0.0259

FCONS_SCORE: 0.9364

RIG_SCORE: 0.5284

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T137R	SIDM01434	Hepatocellular Carcinoma	GDSC	PRTPRRS	DEG_SCF_FBW7_1	0.8987
p.T137R	ACH-000316	Liver Cancer	CCLE	PRTPRRS	DEG_SCF_FBW7_1	0.8987
p.T137M	SIDM02059	Colorectal Carcinoma	GDSC	PRTPRRS	DEG_SCF_FBW7_1	0.8534
p.P138L	DO233898	GACA	ICGC	PRTPRRS	DEG_SCF_FBW7_1	0.7582
p.R136H	TCGA-A5-A0G2	UCEC	TCGA	PRTPRRS	DEG_SCF_FBW7_1	0.7133
p.R136H	TCGA-AG-A02N	READ	TCGA	PRTPRRS	DEG_SCF_FBW7_1	0.7133
p.R136H	DO37146	READ	ICGC	PRTPRRS	DEG_SCF_FBW7_1	0.7133
p.R136H	DO41235	UCEC	ICGC	PRTPRRS	DEG_SCF_FBW7_1	0.7133
p.P135T	DO228971	LICA	ICGC	PRTPRRS	DEG_SCF_FBW7_1	0.7031
p.R139S	DO23216	LINC	ICGC	PRTPRRS	DEG_SCF_FBW7_1	0.6316
p.R139K	DO50970	LICA	ICGC	PRTPRRS	DEG_SCF_FBW7_1	0.6126
p.L132P	SIDM00014	Colorectal Carcinoma	GDSC	PRTPRRS	DEG_SCF_FBW7_1	0.25
p.L132P	LIM1215	large_intestine	COSMIC	PRTPRRS	DEG_SCF_FBW7_1	0.25
p.A147T	DO45223	LIRI	ICGC	PRTPRRS	DEG_SCF_FBW7_1	0.1667
p.P128T	SIDM00270	Head and Neck Carcinoma	GDSC	PRTPRRS	DEG_SCF_FBW7_1	0.1389
p.N126H	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	PRTPRRS	DEG_SCF_FBW7_1	0.0833
p.N126H	ACH-000843	Lung Cancer	CCLE	PRTPRRS	DEG_SCF_FBW7_1	0.0833
p.N126H	HARA	lung	COSMIC	PRTPRRS	DEG_SCF_FBW7_1	0.0833

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26358	DNA	DEG_SCF_FBW7_1	135:141	PRTPRRS	FBXW7	0.9274	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons