DegronMD - P26599(PTBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G350C	TCGA-43-2581	LUSC	TCGA	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.1111
p.G350C	DO26602	LUSC	ICGC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.1111
p.E373K	TCGA-AC-A5XS	BRCA	TCGA	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation substituting flanking lysine	0.1667
p.P372Q	TCGA-D3-A2JL	SKCM	TCGA	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.0833
p.L370R	TCGA-D9-A6EC	SKCM	TCGA	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.1389
p.P355S	TCGA-EY-A215	UCEC	TCGA	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.25
p.P355S	DO42665	UCEC	ICGC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.25
p.A360T	TCGA-XE-A8H5	TGCT	TCGA	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation altering degron motif	0.7139
p.E366K	DO50023	BRCA	ICGC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.25
p.R366L	DO8938	COAD	ICGC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.25
p.L358F	DO228948	LICA	ICGC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation altering degron motif	0.6981
p.V360L	DO220851	MELA	ICGC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation altering degron motif	0.5654
p.Q352H	DO46657	PAAD	ICGC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.1667
p.P365Q	DO47278	SKCM	ICGC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.2778
p.L363R	DO50291	SKCM	ICGC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation altering degron motif	0.8428
p.L354F	DO50288	SKCM	ICGC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.2222
p.R351W	SIDM02055	Colorectal Carcinoma	GDSC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.1389
p.P355L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.25
p.N369S	SIDM00537	Colorectal Carcinoma	GDSC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.1667
p.N369S	GP5d	large intestine	COSMIC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.1667
p.I369V	ACH-000978	Endometrial/Uterine Cancer	CCLE	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.1667
p.I369V	EN	endometrium	COSMIC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.1667
p.L357I	ACH-000986	Colon/Colorectal Cancer	CCLE	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.3056
p.L357I	HT-115	large intestine	COSMIC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.3056
p.Q365H	ACH-002272	Lymphoma	CCLE	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.2778
p.I365V	EN	endometrium	COSMIC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.2778
p.L353I	HT-115	large intestine	COSMIC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.1944
p.N362S	GP5d	large intestine	COSMIC	FGVYGD	LIG_APCC_ABBA_1	358:363	Mutation altering degron motif	0.7069

Kaplan plot for PTBP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTBP1

UniProt ID: P26599

Entrez ID: 5725

Protein name: Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTBP1 in