DegronMD

Uniprot ID: P26599

Source protein: Polypyrimidine tract-binding protein 1

Source gene: PTBP1

Class: LIG_APCC_ABBA_1

Location: 358:363

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.858

ASA_SCORE: 51.9333

COIL: 0.6135

CONS_SCORE: 0.648

DSS_SCORE: 0.0164

HELIX: 0.0808

FCONS_SCORE: 1.2504

RIG_SCORE: 0.9038

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G350C	TCGA-43-2581	LUSC	TCGA	FGVYGD	LIG_APCC_ABBA_1	0.1111
p.G350C	DO26602	LUSC	ICGC	FGVYGD	LIG_APCC_ABBA_1	0.1111
p.E373K	TCGA-AC-A5XS	BRCA	TCGA	FGVYGD	LIG_APCC_ABBA_1	0.1667
p.P372Q	TCGA-D3-A2JL	SKCM	TCGA	FGVYGD	LIG_APCC_ABBA_1	0.0833
p.L370R	TCGA-D9-A6EC	SKCM	TCGA	FGVYGD	LIG_APCC_ABBA_1	0.1389
p.P355S	TCGA-EY-A215	UCEC	TCGA	FGVYGD	LIG_APCC_ABBA_1	0.25
p.P355S	DO42665	UCEC	ICGC	FGVYGD	LIG_APCC_ABBA_1	0.25
p.A360T	TCGA-XE-A8H5	TGCT	TCGA	FGVYGD	LIG_APCC_ABBA_1	0.7139
p.E366K	DO50023	BRCA	ICGC	FGVYGD	LIG_APCC_ABBA_1	0.25
p.R366L	DO8938	COAD	ICGC	FGVYGD	LIG_APCC_ABBA_1	0.25
p.L358F	DO228948	LICA	ICGC	FGVYGD	LIG_APCC_ABBA_1	0.6981
p.V360L	DO220851	MELA	ICGC	FGVYGD	LIG_APCC_ABBA_1	0.5654
p.Q352H	DO46657	PAAD	ICGC	FGVYGD	LIG_APCC_ABBA_1	0.1667
p.P365Q	DO47278	SKCM	ICGC	FGVYGD	LIG_APCC_ABBA_1	0.2778
p.L363R	DO50291	SKCM	ICGC	FGVYGD	LIG_APCC_ABBA_1	0.8428
p.L354F	DO50288	SKCM	ICGC	FGVYGD	LIG_APCC_ABBA_1	0.2222
p.R351W	SIDM02055	Colorectal Carcinoma	GDSC	FGVYGD	LIG_APCC_ABBA_1	0.1389
p.P355L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	FGVYGD	LIG_APCC_ABBA_1	0.25
p.N369S	SIDM00537	Colorectal Carcinoma	GDSC	FGVYGD	LIG_APCC_ABBA_1	0.1667
p.N369S	GP5d	large_intestine	COSMIC	FGVYGD	LIG_APCC_ABBA_1	0.1667
p.I369V	ACH-000978	Endometrial/Uterine Cancer	CCLE	FGVYGD	LIG_APCC_ABBA_1	0.1667
p.I369V	EN	endometrium	COSMIC	FGVYGD	LIG_APCC_ABBA_1	0.1667
p.L357I	ACH-000986	Colon/Colorectal Cancer	CCLE	FGVYGD	LIG_APCC_ABBA_1	0.3056
p.L357I	HT-115	large_intestine	COSMIC	FGVYGD	LIG_APCC_ABBA_1	0.3056
p.Q365H	ACH-002272	Lymphoma	CCLE	FGVYGD	LIG_APCC_ABBA_1	0.2778
p.I365V	EN	endometrium	COSMIC	FGVYGD	LIG_APCC_ABBA_1	0.2778
p.L353I	HT-115	large_intestine	COSMIC	FGVYGD	LIG_APCC_ABBA_1	0.1944
p.N362S	GP5d	large_intestine	COSMIC	FGVYGD	LIG_APCC_ABBA_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26599	Polypyrimidine tract-binding protein 1	LIG_APCC_ABBA_1	358:363	FGVYGD	APC,CDC20,FZR1	0.858	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FGVYGD

Degron related mutations and impact score

Drug responses associated with PTBP1 mutations

All proteins holding degron of FGVYGD