DegronMD - P27824(CANX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P332H	TCGA-66-2734	LUSC	TCGA	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation altering degron motif	0.7694
p.A317T	TCGA-FI-A2D5	UCEC	TCGA	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation rewiring degron network	0.1111
p.P320H	TCGA-N7-A4Y0	UCS	TCGA	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation rewiring degron network	0.1944
p.A336G	TCGA-XR-A8TF	LIHC	TCGA	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation rewiring degron network	0.2778
p.D340N	DO49000	CESC	ICGC	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation rewiring degron network	0.1667
p.I328M	DO52060	HNSC	ICGC	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation altering degron motif	0.7618
p.W322C	DO229029	LICA	ICGC	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation rewiring degron network	0.25
p.D316Y	DO229045	LICA	ICGC	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation rewiring degron network	0.0833
p.D330H	DO45527	LUSC	ICGC	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation altering degron motif	0.7688
p.P329L	DO222595	MELA	ICGC	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation altering degron motif	0.7582
p.W339L	DO37631	SKCM	ICGC	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation rewiring degron network	0.1944
p.P344T	DO37571	SKCM	ICGC	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation rewiring degron network	0.0556
p.D340G	DO41704	UCEC	ICGC	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation rewiring degron network	0.1667
p.E320K	DO43787	UCEC	ICGC	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation rewiring degron network	0.1944
p.P332R	SIDM01679	Small Cell Lung Carcinoma	GDSC	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation altering degron motif	0.7512
p.P332R	ACH-000523	Lung Cancer	CCLE	DDEPEYVPDP	DEG_COP1_1	325:334	Mutation altering degron motif	0.7512

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons