DegronMD

Uniprot ID: P27824

Source protein: Calnexin

Source gene: CANX

Class: DEG_COP1_1

Location: 325:334

E3 ligase: COP1

DEGRON score: 0.8159

ASA_SCORE: 72.4

COIL: 0.7272

CONS_SCORE: 0.6617

DSS_SCORE: 0.8319

HELIX: 0.0663

FCONS_SCORE: 0.9543

RIG_SCORE: 0.6829

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P332H	TCGA-66-2734	LUSC	TCGA	DDEPEYVPDP	DEG_COP1_1	0.7694
p.A317T	TCGA-FI-A2D5	UCEC	TCGA	DDEPEYVPDP	DEG_COP1_1	0.1111
p.P320H	TCGA-N7-A4Y0	UCS	TCGA	DDEPEYVPDP	DEG_COP1_1	0.1944
p.A336G	TCGA-XR-A8TF	LIHC	TCGA	DDEPEYVPDP	DEG_COP1_1	0.2778
p.D340N	DO49000	CESC	ICGC	DDEPEYVPDP	DEG_COP1_1	0.1667
p.I328M	DO52060	HNSC	ICGC	DDEPEYVPDP	DEG_COP1_1	0.7618
p.W322C	DO229029	LICA	ICGC	DDEPEYVPDP	DEG_COP1_1	0.25
p.D316Y	DO229045	LICA	ICGC	DDEPEYVPDP	DEG_COP1_1	0.0833
p.D330H	DO45527	LUSC	ICGC	DDEPEYVPDP	DEG_COP1_1	0.7688
p.P329L	DO222595	MELA	ICGC	DDEPEYVPDP	DEG_COP1_1	0.7582
p.W339L	DO37631	SKCM	ICGC	DDEPEYVPDP	DEG_COP1_1	0.1944
p.P344T	DO37571	SKCM	ICGC	DDEPEYVPDP	DEG_COP1_1	0.0556
p.D340G	DO41704	UCEC	ICGC	DDEPEYVPDP	DEG_COP1_1	0.1667
p.E320K	DO43787	UCEC	ICGC	DDEPEYVPDP	DEG_COP1_1	0.1944
p.P332R	SIDM01679	Small Cell Lung Carcinoma	GDSC	DDEPEYVPDP	DEG_COP1_1	0.7512
p.P332R	ACH-000523	Lung Cancer	CCLE	DDEPEYVPDP	DEG_COP1_1	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27824	Calnexin	DEG_COP1_1	325:334	DDEPEYVPDP	COP1	0.8159	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons