DegronMD - P27987(ITPKB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A290P	TCGA-13-0885	OV	TCGA	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation altering degron motif	0.7503
p.A290P	DO30490	OV	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation altering degron motif	0.7503
p.R309T	TCGA-A2-A0EQ	BRCA	TCGA	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.1389
p.R309T	DO4773	BRCA	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.1389
p.A290D	TCGA-A6-6653	COAD	TCGA	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation altering degron motif	0.7793
p.A290D	DO10373	COAD	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation altering degron motif	0.7793
p.A307T	TCGA-AX-A0J1	UCEC	TCGA	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.1944
p.A307T	DO41199	UCEC	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.1944
p.P283L	TCGA-CG-5723	STAD	TCGA	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.1667
p.P283L	DO38376	STAD	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.1667
p.P291S	TCGA-D9-A6EC	SKCM	TCGA	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation altering degron motif	0.6752
p.P291S	DO50291	SKCM	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation altering degron motif	0.6752
p.S287N	TCGA-GS-A9TZ	DLBC	TCGA	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.2778
p.S287N	DO219918	DLBC	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.2778
p.T301M	DO222755	COCA	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation altering degron motif	0.6312
p.A298D	DO229026	LICA	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation altering degron motif	0.6682
p.T301K	DO229038	LICA	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation altering degron motif	0.6195
p.P283Q	DO229045	LICA	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.1667
p.A290G	DO27847	MALY	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation altering degron motif	0.754
p.A290T	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation altering degron motif	0.7139
p.A290T	ACH-000534	Lymphoma	CCLE	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation altering degron motif	0.7139
p.A290T	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation altering degron motif	0.7139
p.T285N	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.2222
p.T285N	ACH-000706	Lung Cancer	CCLE	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.2222
p.T285N	EKVX	lung	COSMIC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.2222
p.G279D	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.0556
p.G279D	ACH-002254	Lymphoma	CCLE	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.0556
p.G279D	KARPAS-1106P	haematopoietic and lymphoid tissue	COSMIC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.0556
p.A307S	SIDM00489	Oral Cavity Carcinoma	GDSC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.1944
p.A307S	SIDM00807	Bladder Carcinoma	GDSC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.1944
p.A307S	SIDM01372	Pancreatic Carcinoma	GDSC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation rewiring degron network	0.1944
p.L293F	ACH-000395	Lung Cancer	CCLE	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	289:302	Mutation altering degron motif	0.587

Kaplan plot for ITPKB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITPKB

UniProt ID: P27987

Entrez ID: 3707

Protein name: Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITPKB in