DegronMD

Uniprot ID: P27987

Source protein: Inositol-trisphosphate 3-kinase B

Source gene: ITPKB

Class: DEG_ODPH_VHL_1

Location: 289:302

E3 ligase: VHL

DEGRON score: 0.8798

ASA_SCORE: 74.9286

COIL: 0.7782

CONS_SCORE: 0.261

DSS_SCORE: 0.3442

HELIX: 0.1776

FCONS_SCORE: 1.0183

RIG_SCORE: 0.7538

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A290P	TCGA-13-0885	OV	TCGA	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.7503
p.A290P	DO30490	OV	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.7503
p.R309T	TCGA-A2-A0EQ	BRCA	TCGA	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.1389
p.R309T	DO4773	BRCA	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.1389
p.A290D	TCGA-A6-6653	COAD	TCGA	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.7793
p.A290D	DO10373	COAD	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.7793
p.A307T	TCGA-AX-A0J1	UCEC	TCGA	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.1944
p.A307T	DO41199	UCEC	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.1944
p.P283L	TCGA-CG-5723	STAD	TCGA	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.1667
p.P283L	DO38376	STAD	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.1667
p.P291S	TCGA-D9-A6EC	SKCM	TCGA	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.6752
p.P291S	DO50291	SKCM	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.6752
p.S287N	TCGA-GS-A9TZ	DLBC	TCGA	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.2778
p.S287N	DO219918	DLBC	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.2778
p.T301M	DO222755	COCA	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.6312
p.A298D	DO229026	LICA	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.6682
p.T301K	DO229038	LICA	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.6195
p.P283Q	DO229045	LICA	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.1667
p.A290G	DO27847	MALY	ICGC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.754
p.A290T	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.7139
p.A290T	ACH-000534	Lymphoma	CCLE	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.7139
p.A290T	WSU-DLCL2	haematopoietic_and_lymphoid_tissue	COSMIC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.7139
p.T285N	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.2222
p.T285N	ACH-000706	Lung Cancer	CCLE	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.2222
p.T285N	EKVX	lung	COSMIC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.2222
p.G279D	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.0556
p.G279D	ACH-002254	Lymphoma	CCLE	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.0556
p.G279D	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.0556
p.A307S	SIDM00489	Oral Cavity Carcinoma	GDSC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.1944
p.A307S	SIDM00807	Bladder Carcinoma	GDSC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.1944
p.A307S	SIDM01372	Pancreatic Carcinoma	GDSC	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.1944
p.L293F	ACH-000395	Lung Cancer	CCLE	LAPSLGLFGASLTM	DEG_ODPH_VHL_1	0.587

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPSLGLFGASLTM

Degron related mutations and impact score

Drug responses associated with ITPKB mutations

All proteins holding degron of LAPSLGLFGASLTM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27987	Inositol-trisphosphate 3-kinase B	DEG_ODPH_VHL_1	289:302	LAPSLGLFGASLTM	VHL	0.8798	More...