DegronMD - P28331(NDUFS1)

NDUFS1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I18K	TCGA-D1-A1NZ	UCEC	TCGA	VRKALVGLS	DEG_APCC_DBOX_1	6:14	Mutation substituting flanking lysine	0.3333
p.G12C	DO9756	COAD	ICGC	VRKALVGLS	DEG_APCC_DBOX_1	6:14	Mutation altering degron motif	0.6489
p.R22Q	DO219896	DLBC	ICGC	VRKALVGLS	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.1111
p.R22Q	DO41379	UCEC	ICGC	VRKALVGLS	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.1111
p.I4K	DO41536	UCEC	ICGC	VRKALVGLS	DEG_APCC_DBOX_1	6:14	Mutation blocking phosphorylation signal	0.7222
p.K15E	ACH-002014	Eye Cancer	CCLE	VRKALVGLS	DEG_APCC_DBOX_1	6:14	Mutation blocking ubiquitination signal	0.75
p.K15E	ACH-002018	Eye Cancer	CCLE	VRKALVGLS	DEG_APCC_DBOX_1	6:14	Mutation blocking ubiquitination signal	0.75
p.C17F	NCI-H1299	lung	COSMIC	VRKALVGLS	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.25
p.C12F	NCI-H1299	lung	COSMIC	VRKALVGLS	DEG_APCC_DBOX_1	6:14	Mutation altering degron motif	0.7108

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*NOTE: the Kaplan plots were collected from OncoLnc