DegronMD

Uniprot ID: P28331

Source protein: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Source gene: NDUFS1

Class: DEG_APCC_DBOX_1

Location: 6:14

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9126

ASA_SCORE: 89.2778

COIL: 0.735

CONS_SCORE: 0.181

DSS_SCORE: 0.3279

HELIX: 0.2339

FCONS_SCORE: 0.9707

RIG_SCORE: 0.7979

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I18K	TCGA-D1-A1NZ	UCEC	TCGA	VRKALVGLS	DEG_APCC_DBOX_1	0.3333
p.G12C	DO9756	COAD	ICGC	VRKALVGLS	DEG_APCC_DBOX_1	0.6489
p.R22Q	DO219896	DLBC	ICGC	VRKALVGLS	DEG_APCC_DBOX_1	0.1111
p.R22Q	DO41379	UCEC	ICGC	VRKALVGLS	DEG_APCC_DBOX_1	0.1111
p.I4K	DO41536	UCEC	ICGC	VRKALVGLS	DEG_APCC_DBOX_1	0.7222
p.K15E	ACH-002014	Eye Cancer	CCLE	VRKALVGLS	DEG_APCC_DBOX_1	0.75
p.K15E	ACH-002018	Eye Cancer	CCLE	VRKALVGLS	DEG_APCC_DBOX_1	0.75
p.C17F	NCI-H1299	lung	COSMIC	VRKALVGLS	DEG_APCC_DBOX_1	0.25
p.C12F	NCI-H1299	lung	COSMIC	VRKALVGLS	DEG_APCC_DBOX_1	0.7108

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28331	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	DEG_APCC_DBOX_1	6:14	VRKALVGLS	APC,CDC20,FZR1	0.9126	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons