SHC1
UniProt ID: P29353
Entrez ID: 6464
Protein name: SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitmen...
FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}.
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GO - Biological processes (BP):
actin cytoskeleton reorganization [GO:0031532]; angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; cellular response to growth factor stimulus [GO:0071363]; defense response to bacterium [GO:0042742]; epidermal growth factor receptor signaling pathway [GO:0007173]; heart development [GO:000...
actin cytoskeleton reorganization [GO:0031532]; angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; cellular response to growth factor stimulus [GO:0071363]; defense response to bacterium [GO:0042742]; epidermal growth factor receptor signaling pathway [GO:0007173]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of epidermal growth factor-activated receptor activity [GO:0007176]; regulation of growth [GO:0040008]; regulation of superoxide metabolic process [GO:0090322]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]
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GO - Molecular function (MF):
ephrin receptor binding [GO:0046875]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor binding [GO:0005154]; insulin-like growth factor receptor binding [GO:0005159]; insulin receptor binding [GO:0005158]; neurotrophin TRKA receptor binding [GO:0005168]; phospholipid bi...
ephrin receptor binding [GO:0046875]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor binding [GO:0005154]; insulin-like growth factor receptor binding [GO:0005159]; insulin receptor binding [GO:0005158]; neurotrophin TRKA receptor binding [GO:0005168]; phospholipid binding [GO:0005543]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]
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GO - Cellular component (CC):
cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; plasma membrane [GO:0005886]; Shc-EGFR complex [GO:0070435]...
cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; plasma membrane [GO:0005886]; Shc-EGFR complex [GO:0070435]
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SHC1
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*NOTE: the Kaplan plots were collected from OncoLnc