DegronMD

Uniprot ID: P29353

Source protein: SHC-transforming protein 1

Source gene: SHC1

Class: LIG_APCC_ABBA_1

Location: 461:466

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5608

ASA_SCORE: 62.55

COIL: 0.664

CONS_SCORE: 0.311

DSS_SCORE: 0.6043

HELIX: 0.252

FCONS_SCORE: 0.8618

RIG_SCORE: 0.7415

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q476P	TCGA-AX-A1CE	UCEC	TCGA	MKPFED	LIG_APCC_ABBA_1	0.0556
p.E466K	TCGA-B5-A11E	UCEC	TCGA	MKPFED	LIG_APCC_ABBA_1	0.7022
p.E466K	TCGA-BK-A6W3	UCEC	TCGA	MKPFED	LIG_APCC_ABBA_1	0.7022
p.E466K	TCGA-DK-A6AW	BLCA	TCGA	MKPFED	LIG_APCC_ABBA_1	0.7022
p.E466K	TCGA-EI-6917	READ	TCGA	MKPFED	LIG_APCC_ABBA_1	0.7022
p.E466K	ACH-001673	Bile Duct Cancer	CCLE	MKPFED	LIG_APCC_ABBA_1	0.7022
p.R457W	TCGA-CD-A48C	STAD	TCGA	MKPFED	LIG_APCC_ABBA_1	0.2222
p.R457W	TCGA-CV-7422	HNSC	TCGA	MKPFED	LIG_APCC_ABBA_1	0.2222
p.R470H	TCGA-D1-A16X	UCEC	TCGA	MKPFED	LIG_APCC_ABBA_1	0.2222
p.R470C	TCGA-D1-A17Q	UCEC	TCGA	MKPFED	LIG_APCC_ABBA_1	0.2222
p.P474S	ACH-002039	Pancreatic Cancer	CCLE	MKPFED	LIG_APCC_ABBA_1	0.1111
p.G460A	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	MKPFED	LIG_APCC_ABBA_1	0.3056
p.G461A	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	MKPFED	LIG_APCC_ABBA_1	0.754

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29353	SHC-transforming protein 1	LIG_APCC_ABBA_1	461:466	MKPFED	APC,CDC20,FZR1	0.5608	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons