DegronMD - P29376(LTK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S811Y	TCGA-BS-A0UF	UCEC	TCGA	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation rewiring degron network	0.0833
p.S811Y	DO41488	UCEC	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation rewiring degron network	0.0833
p.L807M	TCGA-DU-7294	LGG	TCGA	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation rewiring degron network	0.1944
p.L807M	DO22333	LGG	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation rewiring degron network	0.1944
p.L807M	DO229041	LICA	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation rewiring degron network	0.1944
p.L812V	TCGA-HU-A4GH	STAD	TCGA	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation rewiring degron network	0.0556
p.L812V	DO47743	STAD	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation rewiring degron network	0.0556
p.E801K	TCGA-W3-A825	SKCM	TCGA	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation altering degron motif	0.591
p.E801K	DO51272	SKCM	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation altering degron motif	0.591
p.E800Q	TCGA-XF-A8HC	BLCA	TCGA	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation altering degron motif	0.5633
p.E800Q	DO51908	BLCA	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation altering degron motif	0.5633
p.P792T	DO228952	LICA	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation rewiring degron network	0.25
p.P797T	DO229034	LICA	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation altering degron motif	0.5919
p.R810K	DO229177	LMS	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation rewiring degron network	0.1111
p.P797S	DO52648	MALY	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	795:802	Mutation altering degron motif	0.5641

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons