DegronMD

Uniprot ID: P29376

Source protein: Leukocyte tyrosine kinase receptor

Source gene: LTK

Class: DEG_SCF_FBW7_2

Location: 795:802

E3 ligase: FBXW7

DEGRON score: 0.7128

ASA_SCORE: 85.575

COIL: 0.8938

CONS_SCORE: 0.5142

DSS_SCORE: 0.6538

HELIX: 0.0673

FCONS_SCORE: 1.0007

RIG_SCORE: 0.6195

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S811Y	TCGA-BS-A0UF	UCEC	TCGA	LGPTPEEE	DEG_SCF_FBW7_2	0.0833
p.S811Y	DO41488	UCEC	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	0.0833
p.L807M	TCGA-DU-7294	LGG	TCGA	LGPTPEEE	DEG_SCF_FBW7_2	0.1944
p.L807M	DO22333	LGG	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	0.1944
p.L807M	DO229041	LICA	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	0.1944
p.L812V	TCGA-HU-A4GH	STAD	TCGA	LGPTPEEE	DEG_SCF_FBW7_2	0.0556
p.L812V	DO47743	STAD	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	0.0556
p.E801K	TCGA-W3-A825	SKCM	TCGA	LGPTPEEE	DEG_SCF_FBW7_2	0.591
p.E801K	DO51272	SKCM	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	0.591
p.E800Q	TCGA-XF-A8HC	BLCA	TCGA	LGPTPEEE	DEG_SCF_FBW7_2	0.5633
p.E800Q	DO51908	BLCA	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	0.5633
p.P792T	DO228952	LICA	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	0.25
p.P797T	DO229034	LICA	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	0.5919
p.R810K	DO229177	LMS	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	0.1111
p.P797S	DO52648	MALY	ICGC	LGPTPEEE	DEG_SCF_FBW7_2	0.5641

Drug responses associated with LTK mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00349	ESCA\|oesophagus	p.R569H (No)	GDSC	XMD14-99	194.6844
SIDM00349	ESCA\|oesophagus	p.R569H (No)	GDSC	HG-5-113-01	2.2706
SIDM00572	STAD\|stomach	p.L844I (No)	GDSC	XMD14-99	140.2475
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.P483S (No)	GDSC	XMD14-99	34.2526
SIDM00312	MM\|myeloma	p.P465fs*1 (No)	GDSC	XMD14-99	28.9184
SIDM00683	PRAD\|prostate	p.L685F (No)	GDSC	XMD14-99	33.7129
SIDM00683	PRAD\|prostate	p.L685F (No)	GDSC	HG-5-113-01	7.8398
SIDM00683	PRAD\|prostate	p.R476K (No)	GDSC	XMD14-99	33.7129
SIDM00683	PRAD\|prostate	p.R476K (No)	GDSC	HG-5-113-01	7.8398
SIDM00351	HNSC\|head_and_neck	p.D681Y (No)	GDSC	XMD14-99	79.314
SIDM00382	GBM\|glioma	p.R673W (No)	GDSC	XMD14-99	133.0294
SIDM00382	GBM\|glioma	p.R673W (No)	GDSC	HG-5-113-01	4.57
SIDM00976	SKCM\|melanoma	p.R404G (No)	GDSC	XMD14-99	82.5456
SIDM00976	SKCM\|melanoma	p.R404G (No)	GDSC	HG-5-113-01	5.6947
SIDM00355	LUAD\|lung_NSCLC_adenocarcinoma	p.R569H (No)	GDSC	XMD14-99	133.2708
SIDM00355	LUAD\|lung_NSCLC_adenocarcinoma	p.R569H (No)	GDSC	HG-5-113-01	7.6228
SIDM01007	ALL\|lymphoblastic_leukemia	p.P55S (No)	GDSC	XMD14-99	13.6402
SIDM01007	ALL\|lymphoblastic_leukemia	p.A14V (No)	GDSC	XMD14-99	13.6402
SIDM01174	CESC\|cervix	p.R575Q (No)	GDSC	XMD14-99	188.3415
SIDM00980	STAD\|stomach	p.L150I (No)	GDSC	XMD14-99	106.2381
SIDM00565	HNSC\|head_and_neck	p.V737I (No)	GDSC	XMD14-99	97.0177
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.R673Q (No)	GDSC	XMD14-99	51.1122
SIDM00214	COREAD\|large_intestine	p.C814R (No)	GDSC	XMD14-99	155.6729
SIDM00214	COREAD\|large_intestine	p.C814R (No)	GDSC	HG-5-113-01	2.2376
SIDM00320	LUAD\|lung_NSCLC_adenocarcinoma	p.R682W (No)	GDSC	HG-5-113-01	1.6796
SIDM00988	KIRC\|kidney	p.N509S (No)	GDSC	XMD14-99	111.7341
SIDM00809	HNSC\|head_and_neck	p.P692fs*65 (No)	GDSC	XMD14-99	84.5595
SIDM00946	ALL\|T_cell_leukemia	p.Q396H (No)	GDSC	XMD14-99	7.9361
SIDM00946	ALL\|T_cell_leukemia	p.Q396H (No)	GDSC	HG-5-113-01	2.5595
SIDM01019	LAML\|acute_myeloid_leukaemia	p.W707* (No)	GDSC	XMD14-99	105.4936
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.W454* (No)	GDSC	XMD14-99	68.5465
SIDM00687	STAD\|stomach	p.A654T (No)	GDSC	HG-5-113-01	2.5986
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.G738R (No)	GDSC	XMD14-99	21.084
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.G738R (No)	GDSC	HG-5-113-01	5.0416
SIDM00613	LGG\|glioma	p.K453delK (No)	GDSC	XMD14-99	237.124
SIDM00396	LAML\|acute_myeloid_leukaemia	p.R376P (No)	GDSC	XMD14-99	7.6883
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.P483S (No)	GDSC	XMD14-99	8.0152
SIDM01057	LAML\|acute_myeloid_leukaemia	p.R727C (No)	GDSC	XMD14-99	19.6148
SIDM00150	COREAD\|large_intestine	p.R138L (No)	GDSC	XMD14-99	54.3505
SIDM00150	COREAD\|large_intestine	p.R138L (No)	GDSC	HG-5-113-01	4.4045
SIDM00969	OV\|ovary	p.V737A (No)	GDSC	XMD14-99	98.2193
SIDM00969	OV\|ovary	p.V737A (No)	GDSC	HG-5-113-01	1.142
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.A472fs*>8 (No)	GDSC	XMD14-99	93.2576
SIDM00789	COREAD\|large_intestine	p.P424L (No)	GDSC	XMD14-99	118.029
SIDM00789	COREAD\|large_intestine	p.P424L (No)	GDSC	HG-5-113-01	18.9124
SIDM00789	COREAD\|large_intestine	p.G153W (No)	GDSC	XMD14-99	118.029
SIDM00789	COREAD\|large_intestine	p.G153W (No)	GDSC	HG-5-113-01	18.9124
SIDM00649	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P463R (No)	GDSC	XMD14-99	221.9562
SIDM00861	UNCLASSIFIED\|ovary	p.P41S (No)	GDSC	XMD14-99	91.3912
SIDM00861	UNCLASSIFIED\|ovary	p.P41S (No)	GDSC	HG-5-113-01	25.6802
SIDM01127	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.R682W (No)	GDSC	XMD14-99	189.9626
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.Y779H (No)	GDSC	XMD14-99	134.1623
SIDM00225	SKCM\|melanoma	p.R647G (No)	GDSC	XMD14-99	111.5951
SIDM00225	SKCM\|melanoma	p.R647G (No)	GDSC	HG-5-113-01	4.0626
SIDM01205	DLBC\|B_cell_lymphoma	p.A472fs*>8 (No)	GDSC	XMD14-99	22.6464
SIDM01205	DLBC\|B_cell_lymphoma	p.A472fs*>8 (No)	GDSC	HG-5-113-01	0.8479
SIDM00373	UCEC\|endometrium	p.A480T (No)	GDSC	XMD14-99	30.322
SIDM00373	UCEC\|endometrium	p.A480T (No)	GDSC	HG-5-113-01	1.6901
SIDM00503	STAD\|stomach	p.W707* (No)	GDSC	XMD14-99	67.0538
SIDM00346	LCML\|chronic_myeloid_leukaemia	p.R741W (No)	GDSC	XMD14-99	24.0597
SIDM01027	ESCA\|oesophagus	p.V373I (No)	GDSC	XMD14-99	42.0754
SIDM01027	ESCA\|oesophagus	p.V373I (No)	GDSC	HG-5-113-01	3.2857
SIDM00875	UNCLASSIFIED\|breast	p.R767C (No)	GDSC	XMD14-99	51.4054
SIDM00875	UNCLASSIFIED\|breast	p.R741Q (No)	GDSC	XMD14-99	51.4054
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.R682W (No)	GDSC	XMD14-99	35.1092
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.R682W (No)	GDSC	HG-5-113-01	6.2959
SIDM00832	COREAD\|large_intestine	p.S471fs*>7 (No)	GDSC	XMD14-99	369.5773
SIDM00832	COREAD\|large_intestine	p.S471fs*>7 (No)	GDSC	HG-5-113-01	7.0302

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LGPTPEEE

Degron related mutations and impact score

Drug responses associated with LTK mutations

All proteins holding degron of LGPTPEEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29376	Leukocyte tyrosine kinase receptor	DEG_SCF_FBW7_2	795:802	LGPTPEEE	FBXW7	0.7128	More...