DegronMD - P30086(PEBP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K62Q	TCGA-19-5956	GBM	TCGA	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation altering degron motif	0.5833
p.K62Q	DO13863	GBM	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation altering degron motif	0.5833
p.L58V	TCGA-61-2003	OV	TCGA	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.3056
p.L58V	TCGA-97-7938	LUAD	TCGA	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.3056
p.L58V	DO24329	LUAD	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.3056
p.L58V	DO31300	OV	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.3056
p.G57V	TCGA-66-2792	LUSC	TCGA	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.2778
p.G57V	DO26451	LUSC	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.2778
p.S54L	TCGA-B5-A0JY	UCEC	TCGA	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation blocking phosphorylation signal	0.6389
p.S54L	DO37782	SKCM	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation blocking phosphorylation signal	0.6389
p.S54L	DO43041	UCEC	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation blocking phosphorylation signal	0.6389
p.D70Y	TCGA-BF-A1PZ	SKCM	TCGA	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.1944
p.D70Y	DO50279	SKCM	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.1944
p.L68P	DO222755	COCA	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.25
p.S75I	DO232224	PBCA	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation blocking phosphorylation signal	0.5
p.S52R	DO230657	PRAD	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation blocking phosphorylation signal	0.5833
p.D56G	DO233487	PRAD	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.25
p.S75N	SIDM02041	Colorectal Carcinoma	GDSC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation blocking phosphorylation signal	0.5
p.L58H	SIDM01304	Colorectal Carcinoma	GDSC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.3056
p.R49T	SIDM00216	Colorectal Carcinoma	GDSC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.0556
p.R49T	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.0556
p.R49T	SNU-175	large intestine	COSMIC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.0556
p.P50A	SIDM00562	Breast Carcinoma	GDSC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.0833
p.P50A	ACH-002163	Breast Cancer	CCLE	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.0833
p.P50A	MRK-nu-1	breast	COSMIC	DSGKLYT	DEG_SCF_TRCP1_1	59:65	Mutation rewiring degron network	0.0833

Kaplan plot for PEBP1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PEBP1

UniProt ID: P30086

Entrez ID: 5037

Protein name: Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PEBP1 in