DegronMD

Uniprot ID: P30086

Source protein: Phosphatidylethanolamine-binding protein 1

Source gene: PEBP1

Class: DEG_SCF_TRCP1_1

Location: 59:65

E3 ligase: BTRC

DEGRON score: 0.8262

ASA_SCORE: 42.5857

COIL: 0.4891

CONS_SCORE: 0.4872

DSS_SCORE: 0.2659

HELIX: 0.0243

FCONS_SCORE: 0.8608

RIG_SCORE: 0.7906

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K62Q	TCGA-19-5956	GBM	TCGA	DSGKLYT	DEG_SCF_TRCP1_1	0.5833
p.K62Q	DO13863	GBM	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	0.5833
p.L58V	TCGA-61-2003	OV	TCGA	DSGKLYT	DEG_SCF_TRCP1_1	0.3056
p.L58V	TCGA-97-7938	LUAD	TCGA	DSGKLYT	DEG_SCF_TRCP1_1	0.3056
p.L58V	DO24329	LUAD	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	0.3056
p.L58V	DO31300	OV	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	0.3056
p.G57V	TCGA-66-2792	LUSC	TCGA	DSGKLYT	DEG_SCF_TRCP1_1	0.2778
p.G57V	DO26451	LUSC	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	0.2778
p.S54L	TCGA-B5-A0JY	UCEC	TCGA	DSGKLYT	DEG_SCF_TRCP1_1	0.6389
p.S54L	DO37782	SKCM	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	0.6389
p.S54L	DO43041	UCEC	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	0.6389
p.D70Y	TCGA-BF-A1PZ	SKCM	TCGA	DSGKLYT	DEG_SCF_TRCP1_1	0.1944
p.D70Y	DO50279	SKCM	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	0.1944
p.L68P	DO222755	COCA	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	0.25
p.S75I	DO232224	PBCA	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	0.5
p.S52R	DO230657	PRAD	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	0.5833
p.D56G	DO233487	PRAD	ICGC	DSGKLYT	DEG_SCF_TRCP1_1	0.25
p.S75N	SIDM02041	Colorectal Carcinoma	GDSC	DSGKLYT	DEG_SCF_TRCP1_1	0.5
p.L58H	SIDM01304	Colorectal Carcinoma	GDSC	DSGKLYT	DEG_SCF_TRCP1_1	0.3056
p.R49T	SIDM00216	Colorectal Carcinoma	GDSC	DSGKLYT	DEG_SCF_TRCP1_1	0.0556
p.R49T	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGKLYT	DEG_SCF_TRCP1_1	0.0556
p.R49T	SNU-175	large_intestine	COSMIC	DSGKLYT	DEG_SCF_TRCP1_1	0.0556
p.P50A	SIDM00562	Breast Carcinoma	GDSC	DSGKLYT	DEG_SCF_TRCP1_1	0.0833
p.P50A	ACH-002163	Breast Cancer	CCLE	DSGKLYT	DEG_SCF_TRCP1_1	0.0833
p.P50A	MRK-nu-1	breast	COSMIC	DSGKLYT	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30086	Phosphatidylethanolamine-binding protein 1	DEG_SCF_TRCP1_1	59:65	DSGKLYT	BTRC	0.8262	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons