DegronMD - P31146(CORO1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A368T	TCGA-AA-A022	COAD	TCGA	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.1389
p.A368T	TCGA-C5-A7X5	CESC	TCGA	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.1389
p.A368T	DO49894	CESC	ICGC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.1389
p.A368T	DO10647	COAD	ICGC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.1389
p.D371E	TCGA-CD-8531	STAD	TCGA	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.0556
p.D371E	DO47877	STAD	ICGC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.0556
p.R354Q	TCGA-XF-AAMQ	BLCA	TCGA	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.3056
p.R354Q	DO51934	BLCA	ICGC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.3056
p.R354Q	SIDM00447	B-Lymphoblastic Leukemia	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.3056
p.R354Q	ACH-000960	Leukemia	CCLE	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.3056
p.R354Q	REH	haematopoietic and lymphoid tissue	COSMIC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.3056
p.S356L	DO233823	GACA	ICGC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation altering degron motif	0.7667
p.P366H	SIDM01245	T-Lymphoblastic Leukemia	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.1944
p.P366H	SIDM00139	Mesothelioma	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.1944
p.P366H	SIDM00685	Glioblastoma	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.1944
p.P366H	SIDM00991	T-Lymphoblastic Leukemia	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.1944
p.P366H	SIDM01491	Colorectal Carcinoma	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.1944
p.P366H	SIDM01525	Acute Myeloid Leukemia	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.1944
p.A368S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.1389
p.A368S	ACH-002222	Leukemia	CCLE	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.1389
p.A368S	CTV-1	haematopoietic and lymphoid tissue	COSMIC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	355:361	Mutation rewiring degron network	0.1389

Kaplan plot for CORO1A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CORO1A

UniProt ID: P31146

Entrez ID: 11151

Protein name: Coronin-1A (Coronin-like protein A) (Clipin-A) (Coronin-like protein p57) (Tryptophan aspartate-containing coat protein) (TACO)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CORO1A in