DegronMD

Uniprot ID: P31146

Source protein: Coronin-1A

Source gene: CORO1A

Class: LIG_APCC_ABBAyCdc20_2

Location: 355:361

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9957

ASA_SCORE: 71.7286

COIL: 0.6604

CONS_SCORE: 0.6961

DSS_SCORE: 0.4373

HELIX: 0.2106

FCONS_SCORE: 1.0774

RIG_SCORE: 0.7746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A368T	TCGA-AA-A022	COAD	TCGA	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A368T	TCGA-C5-A7X5	CESC	TCGA	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A368T	DO49894	CESC	ICGC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A368T	DO10647	COAD	ICGC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D371E	TCGA-CD-8531	STAD	TCGA	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D371E	DO47877	STAD	ICGC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R354Q	TCGA-XF-AAMQ	BLCA	TCGA	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R354Q	DO51934	BLCA	ICGC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R354Q	SIDM00447	B-Lymphoblastic Leukemia	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R354Q	ACH-000960	Leukemia	CCLE	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R354Q	REH	haematopoietic_and_lymphoid_tissue	COSMIC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S356L	DO233823	GACA	ICGC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.7667
p.P366H	SIDM01245	T-Lymphoblastic Leukemia	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P366H	SIDM00139	Mesothelioma	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P366H	SIDM00685	Glioblastoma	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P366H	SIDM00991	T-Lymphoblastic Leukemia	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P366H	SIDM01491	Colorectal Carcinoma	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P366H	SIDM01525	Acute Myeloid Leukemia	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A368S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A368S	ACH-002222	Leukemia	CCLE	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A368S	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	KSDLFQE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31146	Coronin-1A	LIG_APCC_ABBAyCdc20_2	355:361	KSDLFQE	APC,CDC20,FZR1	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KSDLFQE

Degron related mutations and impact score

Drug responses associated with CORO1A mutations

All proteins holding degron of KSDLFQE