DegronMD - P31944(CASP14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A119V	TCGA-63-A5MM	LUSC	TCGA	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.0556
p.A119V	TCGA-AP-A1DK	UCEC	TCGA	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.0556
p.A119V	DO219153	LUSC	ICGC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.0556
p.A119V	DO42033	UCEC	ICGC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.0556
p.K125N	TCGA-BF-A1Q0	SKCM	TCGA	IQACRGEQR	SCF_FBXL2	129:137	Mutation substituting flanking lysine	0.3333
p.K125N	DO47374	SKCM	ICGC	IQACRGEQR	SCF_FBXL2	129:137	Mutation substituting flanking lysine	0.3333
p.R121Q	TCGA-K4-A54R	BLCA	TCGA	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.1111
p.R121Q	DO48611	BLCA	ICGC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.1111
p.R121Q	DO233760	GACA	ICGC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.1111
p.R121Q	ACH-001412	Bladder Cancer	CCLE	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.1111
p.E135K	TCGA-VQ-A922	STAD	TCGA	IQACRGEQR	SCF_FBXL2	129:137	Mutation altering degron motif	0.591
p.E135K	DO51794	STAD	ICGC	IQACRGEQR	SCF_FBXL2	129:137	Mutation altering degron motif	0.591
p.D138N	DO6231	BRCA	ICGC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.3056
p.G144V	DO228928	LICA	ICGC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.1389
p.E141K	DO229456	SKCA	ICGC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.2222
p.E141K	SIDM01042	Breast Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.2222
p.E141K	ACH-001065	Breast Cancer	CCLE	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.2222
p.E141K	EVSA-T	breast	COSMIC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.2222
p.P139S	SIDM00773	Non-Cancerous	GDSC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.2778
p.P139S	SIDM00845	Burkitt's Lymphoma	GDSC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.2778
p.P139S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.2778
p.P139S	SIDM00774	Breast Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.2778
p.A122D	SIDM00789	Colorectal Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.1389
p.A122D	ACH-000997	Colon/Colorectal Cancer	CCLE	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.1389
p.A122D	ACH-001061	Colon/Colorectal Cancer	CCLE	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.1389
p.A122D	ACH-001957	Bone Cancer	CCLE	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.1389
p.A122D	HCT-15	large intestine	COSMIC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.1389
p.I128N	SIDM00695	Melanoma	GDSC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.3056
p.G145V	SIDM01129	Small Cell Lung Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.1111
p.G145V	ACH-000816	Lung Cancer	CCLE	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.1111
p.G145V	NCI-H524	lung	COSMIC	IQACRGEQR	SCF_FBXL2	129:137	Mutation rewiring degron network	0.1111
p.G134V	SIDM00282	Colorectal Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	129:137	Mutation altering degron motif	0.7532
p.G134V	ACH-000998	Colon/Colorectal Cancer	CCLE	IQACRGEQR	SCF_FBXL2	129:137	Mutation altering degron motif	0.7532
p.G134V	CW-2	large intestine	COSMIC	IQACRGEQR	SCF_FBXL2	129:137	Mutation altering degron motif	0.7532
p.Q130E	ACH-001057	Lymphoma	CCLE	IQACRGEQR	SCF_FBXL2	129:137	Mutation altering degron motif	0.6744

Kaplan plot for CASP14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CASP14

UniProt ID: P31944

Entrez ID: 23581

Protein name: Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CASP14 in