DegronMD

Uniprot ID: P31944

Source protein: Caspase-14

Source gene: CASP14

Class: SCF_FBXL2

Location: 129:137

E3 ligase: FBXL2

DEGRON score: 0.923

ASA_SCORE: 54.8667

COIL: 0.5948

CONS_SCORE: 0.9115

DSS_SCORE: 0.3287

HELIX: 0.0292

FCONS_SCORE: 1.307

RIG_SCORE: 0.7794

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G134V	SIDM00282	Colorectal Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	0.7532
p.G134V	ACH-000998	Colon/Colorectal Cancer	CCLE	IQACRGEQR	SCF_FBXL2	0.7532
p.G134V	CW-2	large_intestine	COSMIC	IQACRGEQR	SCF_FBXL2	0.7532
p.Q130E	ACH-001057	Lymphoma	CCLE	IQACRGEQR	SCF_FBXL2	0.6744
p.E135K	TCGA-VQ-A922	STAD	TCGA	IQACRGEQR	SCF_FBXL2	0.591
p.E135K	DO51794	STAD	ICGC	IQACRGEQR	SCF_FBXL2	0.591
p.K125N	TCGA-BF-A1Q0	SKCM	TCGA	IQACRGEQR	SCF_FBXL2	0.3333
p.K125N	DO47374	SKCM	ICGC	IQACRGEQR	SCF_FBXL2	0.3333
p.D138N	DO6231	BRCA	ICGC	IQACRGEQR	SCF_FBXL2	0.3056
p.I128N	SIDM00695	Melanoma	GDSC	IQACRGEQR	SCF_FBXL2	0.3056
p.P139S	SIDM00773	Non-Cancerous	GDSC	IQACRGEQR	SCF_FBXL2	0.2778
p.P139S	SIDM00845	Burkitt's Lymphoma	GDSC	IQACRGEQR	SCF_FBXL2	0.2778
p.P139S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	0.2778
p.P139S	SIDM00774	Breast Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	0.2778
p.E141K	DO229456	SKCA	ICGC	IQACRGEQR	SCF_FBXL2	0.2222
p.E141K	SIDM01042	Breast Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	0.2222
p.E141K	ACH-001065	Breast Cancer	CCLE	IQACRGEQR	SCF_FBXL2	0.2222
p.E141K	EVSA-T	breast	COSMIC	IQACRGEQR	SCF_FBXL2	0.2222
p.G144V	DO228928	LICA	ICGC	IQACRGEQR	SCF_FBXL2	0.1389
p.A122D	SIDM00789	Colorectal Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	0.1389
p.A122D	ACH-000997	Colon/Colorectal Cancer	CCLE	IQACRGEQR	SCF_FBXL2	0.1389
p.A122D	ACH-001061	Colon/Colorectal Cancer	CCLE	IQACRGEQR	SCF_FBXL2	0.1389
p.A122D	ACH-001957	Bone Cancer	CCLE	IQACRGEQR	SCF_FBXL2	0.1389
p.A122D	HCT-15	large_intestine	COSMIC	IQACRGEQR	SCF_FBXL2	0.1389
p.R121Q	TCGA-K4-A54R	BLCA	TCGA	IQACRGEQR	SCF_FBXL2	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31944	Caspase-14	SCF_FBXL2	129:137	IQACRGEQR	FBXL2	0.923	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons