DegronMD

Uniprot ID: P31944

Source protein: Caspase-14

Source gene: CASP14

Class: SCF_FBXL2

Location: 129:137

E3 ligase: FBXL2

DEGRON score: 0.923

ASA_SCORE: 54.8667

COIL: 0.5948

CONS_SCORE: 0.9115

DSS_SCORE: 0.3287

HELIX: 0.0292

FCONS_SCORE: 1.307

RIG_SCORE: 0.7794

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A119V	TCGA-63-A5MM	LUSC	TCGA	IQACRGEQR	SCF_FBXL2	0.0556
p.A119V	TCGA-AP-A1DK	UCEC	TCGA	IQACRGEQR	SCF_FBXL2	0.0556
p.A119V	DO219153	LUSC	ICGC	IQACRGEQR	SCF_FBXL2	0.0556
p.A119V	DO42033	UCEC	ICGC	IQACRGEQR	SCF_FBXL2	0.0556
p.K125N	TCGA-BF-A1Q0	SKCM	TCGA	IQACRGEQR	SCF_FBXL2	0.3333
p.K125N	DO47374	SKCM	ICGC	IQACRGEQR	SCF_FBXL2	0.3333
p.R121Q	TCGA-K4-A54R	BLCA	TCGA	IQACRGEQR	SCF_FBXL2	0.1111
p.R121Q	DO48611	BLCA	ICGC	IQACRGEQR	SCF_FBXL2	0.1111
p.R121Q	DO233760	GACA	ICGC	IQACRGEQR	SCF_FBXL2	0.1111
p.R121Q	ACH-001412	Bladder Cancer	CCLE	IQACRGEQR	SCF_FBXL2	0.1111
p.E135K	TCGA-VQ-A922	STAD	TCGA	IQACRGEQR	SCF_FBXL2	0.591
p.E135K	DO51794	STAD	ICGC	IQACRGEQR	SCF_FBXL2	0.591
p.D138N	DO6231	BRCA	ICGC	IQACRGEQR	SCF_FBXL2	0.3056
p.G144V	DO228928	LICA	ICGC	IQACRGEQR	SCF_FBXL2	0.1389
p.E141K	DO229456	SKCA	ICGC	IQACRGEQR	SCF_FBXL2	0.2222
p.E141K	SIDM01042	Breast Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	0.2222
p.E141K	ACH-001065	Breast Cancer	CCLE	IQACRGEQR	SCF_FBXL2	0.2222
p.E141K	EVSA-T	breast	COSMIC	IQACRGEQR	SCF_FBXL2	0.2222
p.P139S	SIDM00773	Non-Cancerous	GDSC	IQACRGEQR	SCF_FBXL2	0.2778
p.P139S	SIDM00845	Burkitt's Lymphoma	GDSC	IQACRGEQR	SCF_FBXL2	0.2778
p.P139S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	0.2778
p.P139S	SIDM00774	Breast Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	0.2778
p.A122D	SIDM00789	Colorectal Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	0.1389
p.A122D	ACH-000997	Colon/Colorectal Cancer	CCLE	IQACRGEQR	SCF_FBXL2	0.1389
p.A122D	ACH-001061	Colon/Colorectal Cancer	CCLE	IQACRGEQR	SCF_FBXL2	0.1389
p.A122D	ACH-001957	Bone Cancer	CCLE	IQACRGEQR	SCF_FBXL2	0.1389
p.A122D	HCT-15	large_intestine	COSMIC	IQACRGEQR	SCF_FBXL2	0.1389
p.I128N	SIDM00695	Melanoma	GDSC	IQACRGEQR	SCF_FBXL2	0.3056
p.G145V	SIDM01129	Small Cell Lung Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	0.1111
p.G145V	ACH-000816	Lung Cancer	CCLE	IQACRGEQR	SCF_FBXL2	0.1111
p.G145V	NCI-H524	lung	COSMIC	IQACRGEQR	SCF_FBXL2	0.1111
p.G134V	SIDM00282	Colorectal Carcinoma	GDSC	IQACRGEQR	SCF_FBXL2	0.7532
p.G134V	ACH-000998	Colon/Colorectal Cancer	CCLE	IQACRGEQR	SCF_FBXL2	0.7532
p.G134V	CW-2	large_intestine	COSMIC	IQACRGEQR	SCF_FBXL2	0.7532
p.Q130E	ACH-001057	Lymphoma	CCLE	IQACRGEQR	SCF_FBXL2	0.6744

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IQACRGEQR

Degron related mutations and impact score

Drug responses associated with CASP14 mutations

All proteins holding degron of IQACRGEQR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31944	Caspase-14	SCF_FBXL2	129:137	IQACRGEQR	FBXL2	0.923	More...