DegronMD - P31997(CEACAM8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L129I	TCGA-A5-A2K5	UCEC	TCGA	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.L129I	TCGA-DK-A6AW	BLCA	TCGA	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.L129I	DO48566	BLCA	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.L129I	DO41379	UCEC	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.P142L	TCGA-AP-A051	UCEC	TCGA	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6471
p.P142L	TCGA-FI-A2D5	UCEC	TCGA	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6471
p.P142L	DO229061	LICA	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6471
p.P142L	DO42673	UCEC	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6471
p.P142L	DO41331	UCEC	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6471
p.P142L	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6471
p.E143D	TCGA-C5-A7CO	CESC	TCGA	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5647
p.E143D	DO49888	CESC	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5647
p.L129H	TCGA-D7-A4Z0	STAD	TCGA	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.L129H	DO47765	STAD	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.E143K	TCGA-D8-A27G	BRCA	TCGA	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.7022
p.E143K	DO5465	BRCA	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.7022
p.E132K	TCGA-DK-A3IS	BLCA	TCGA	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1667
p.E132K	DO566	BLCA	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1667
p.M130I	TCGA-DK-A3IS	BLCA	TCGA	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1111
p.M130I	DO566	BLCA	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1111
p.P142S	TCGA-EE-A2A6	SKCM	TCGA	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5641
p.P142S	TCGA-G2-A2EJ	BLCA	TCGA	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5641
p.P142S	DO554	BLCA	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5641
p.P142S	DO222390	MELA	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5641
p.P142S	DO37591	SKCM	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5641
p.P142S	SIDM00217	Colorectal Carcinoma	GDSC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5641
p.P142S	SNU-1040	large intestine	COSMIC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5641
p.P142Q	TCGA-GJ-A9DB	LIHC	TCGA	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5924
p.P142Q	DO52301	LIHC	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5924
p.L129R	DO50439	ESAD	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.V140I	DO233111	GACA	ICGC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5965
p.P142T	SIDM00934	Pancreatic Carcinoma	GDSC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5919
p.P145H	SIDM01387	Small Cell Lung Carcinoma	GDSC	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2778
p.P145H	ACH-000921	Lung Cancer	CCLE	FSVHPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2778

Kaplan plot for CEACAM8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEACAM8

UniProt ID: P31997

Entrez ID: 1088

Protein name: Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEACAM8 in