DegronMD

Uniprot ID: P31997

Source protein: Carcinoembryonic antigen-related cell adhesion molecule 8

Source gene: CEACAM8

Class: LIG_APCC_ABBA_1

Location: 138:143

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7041

ASA_SCORE: 42.3167

COIL: 0.3863

CONS_SCORE: 0.5455

DSS_SCORE: 0.5842

HELIX: 0.0115

FCONS_SCORE: 1.1797

RIG_SCORE: 0.6978

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L129I	TCGA-A5-A2K5	UCEC	TCGA	FSVHPE	LIG_APCC_ABBA_1	0.0833
p.L129I	TCGA-DK-A6AW	BLCA	TCGA	FSVHPE	LIG_APCC_ABBA_1	0.0833
p.L129I	DO48566	BLCA	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.0833
p.L129I	DO41379	UCEC	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.0833
p.P142L	TCGA-AP-A051	UCEC	TCGA	FSVHPE	LIG_APCC_ABBA_1	0.6471
p.P142L	TCGA-FI-A2D5	UCEC	TCGA	FSVHPE	LIG_APCC_ABBA_1	0.6471
p.P142L	DO229061	LICA	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.6471
p.P142L	DO42673	UCEC	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.6471
p.P142L	DO41331	UCEC	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.6471
p.P142L	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	FSVHPE	LIG_APCC_ABBA_1	0.6471
p.E143D	TCGA-C5-A7CO	CESC	TCGA	FSVHPE	LIG_APCC_ABBA_1	0.5647
p.E143D	DO49888	CESC	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.5647
p.L129H	TCGA-D7-A4Z0	STAD	TCGA	FSVHPE	LIG_APCC_ABBA_1	0.0833
p.L129H	DO47765	STAD	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.0833
p.E143K	TCGA-D8-A27G	BRCA	TCGA	FSVHPE	LIG_APCC_ABBA_1	0.7022
p.E143K	DO5465	BRCA	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.7022
p.E132K	TCGA-DK-A3IS	BLCA	TCGA	FSVHPE	LIG_APCC_ABBA_1	0.1667
p.E132K	DO566	BLCA	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.1667
p.M130I	TCGA-DK-A3IS	BLCA	TCGA	FSVHPE	LIG_APCC_ABBA_1	0.1111
p.M130I	DO566	BLCA	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.1111
p.P142S	TCGA-EE-A2A6	SKCM	TCGA	FSVHPE	LIG_APCC_ABBA_1	0.5641
p.P142S	TCGA-G2-A2EJ	BLCA	TCGA	FSVHPE	LIG_APCC_ABBA_1	0.5641
p.P142S	DO554	BLCA	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.5641
p.P142S	DO222390	MELA	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.5641
p.P142S	DO37591	SKCM	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.5641
p.P142S	SIDM00217	Colorectal Carcinoma	GDSC	FSVHPE	LIG_APCC_ABBA_1	0.5641
p.P142S	SNU-1040	large_intestine	COSMIC	FSVHPE	LIG_APCC_ABBA_1	0.5641
p.P142Q	TCGA-GJ-A9DB	LIHC	TCGA	FSVHPE	LIG_APCC_ABBA_1	0.5924
p.P142Q	DO52301	LIHC	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.5924
p.L129R	DO50439	ESAD	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.0833
p.V140I	DO233111	GACA	ICGC	FSVHPE	LIG_APCC_ABBA_1	0.5965
p.P142T	SIDM00934	Pancreatic Carcinoma	GDSC	FSVHPE	LIG_APCC_ABBA_1	0.5919
p.P145H	SIDM01387	Small Cell Lung Carcinoma	GDSC	FSVHPE	LIG_APCC_ABBA_1	0.2778
p.P145H	ACH-000921	Lung Cancer	CCLE	FSVHPE	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FSVHPE

Degron related mutations and impact score

Drug responses associated with CEACAM8 mutations

All proteins holding degron of FSVHPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31997	Carcinoembryonic antigen-related cell adhesion molecule 8	LIG_APCC_ABBA_1	138:143	FSVHPE	APC,CDC20,FZR1	0.7041	More...