DegronMD - P32241(VIPR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R324W	TCGA-AA-3949	COAD	TCGA	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation altering degron motif	0.7523
p.R324W	SIDM00946	T-Lymphoblastic Leukemia	GDSC	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation altering degron motif	0.7523
p.R324W	ACH-000981	Leukemia	CCLE	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation altering degron motif	0.7523
p.R324W	DND-41	haematopoietic and lymphoid tissue	COSMIC	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation altering degron motif	0.7523
p.R317Q	TCGA-AG-A002	READ	TCGA	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation altering degron motif	0.7329
p.K330N	TCGA-EE-A20C	SKCM	TCGA	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation substituting flanking lysine	0.2778
p.Q321L	TCGA-PC-A5DK	SARC	TCGA	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation altering degron motif	0.6654
p.V327I	DO581	BLCA	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation rewiring degron network	0.25
p.V327I	DO234278	ESAD	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation rewiring degron network	0.25
p.V328M	DO222737	COCA	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation rewiring degron network	0.2222
p.M308I	DO229018	LICA	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation rewiring degron network	0.1111
p.E319K	DO52262	LIHC	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation altering degron motif	0.7022
p.D314N	DO222595	MELA	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation rewiring degron network	0.2778
p.P313S	DO222572	MELA	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation rewiring degron network	0.25
p.N315T	DO36556	READ	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation rewiring degron network	0.3056
p.N315K	DO36556	READ	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation rewiring degron network	0.3056
p.V327A	DO42280	UCEC	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation rewiring degron network	0.25
p.L311P	SIDM00192	Colorectal Carcinoma	GDSC	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation rewiring degron network	0.1944
p.L311P	ACH-000286	Colon/Colorectal Cancer	CCLE	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation rewiring degron network	0.1944
p.G329E	CW-2	large intestine	COSMIC	IRILLQKLR	DEG_APCC_DBOX_1	316:324	Mutation rewiring degron network	0.1944

Kaplan plot for VIPR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VIPR1

UniProt ID: P32241

Entrez ID: 7433

Protein name: Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VIPR1 in