DegronMD

Uniprot ID: P32241

Source protein: Vasoactive intestinal polypeptide receptor 1

Source gene: VIPR1

Class: DEG_APCC_DBOX_1

Location: 316:324

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5252

ASA_SCORE: 84.1778

COIL: 0.3249

CONS_SCORE: 0.629

DSS_SCORE: 0.0118

HELIX: 0.6608

FCONS_SCORE: 1.2798

RIG_SCORE: 0.9786

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R324W	TCGA-AA-3949	COAD	TCGA	IRILLQKLR	DEG_APCC_DBOX_1	0.7523
p.R324W	SIDM00946	T-Lymphoblastic Leukemia	GDSC	IRILLQKLR	DEG_APCC_DBOX_1	0.7523
p.R324W	ACH-000981	Leukemia	CCLE	IRILLQKLR	DEG_APCC_DBOX_1	0.7523
p.R324W	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	IRILLQKLR	DEG_APCC_DBOX_1	0.7523
p.R317Q	TCGA-AG-A002	READ	TCGA	IRILLQKLR	DEG_APCC_DBOX_1	0.7329
p.E319K	DO52262	LIHC	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	0.7022
p.Q321L	TCGA-PC-A5DK	SARC	TCGA	IRILLQKLR	DEG_APCC_DBOX_1	0.6654
p.N315T	DO36556	READ	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	0.3056
p.N315K	DO36556	READ	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	0.3056
p.K330N	TCGA-EE-A20C	SKCM	TCGA	IRILLQKLR	DEG_APCC_DBOX_1	0.2778
p.D314N	DO222595	MELA	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	0.2778
p.V327I	DO581	BLCA	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	0.25
p.V327I	DO234278	ESAD	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	0.25
p.P313S	DO222572	MELA	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	0.25
p.V327A	DO42280	UCEC	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	0.25
p.V328M	DO222737	COCA	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	0.2222
p.L311P	SIDM00192	Colorectal Carcinoma	GDSC	IRILLQKLR	DEG_APCC_DBOX_1	0.1944
p.L311P	ACH-000286	Colon/Colorectal Cancer	CCLE	IRILLQKLR	DEG_APCC_DBOX_1	0.1944
p.G329E	CW-2	large_intestine	COSMIC	IRILLQKLR	DEG_APCC_DBOX_1	0.1944
p.M308I	DO229018	LICA	ICGC	IRILLQKLR	DEG_APCC_DBOX_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P32241	Vasoactive intestinal polypeptide receptor 1	DEG_APCC_DBOX_1	316:324	IRILLQKLR	APC,CDC20,FZR1	0.5252	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons