DegronMD - P32519(ELF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R184L	TCGA-80-5611	LUAD	TCGA	PATTPNIS	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.2222
p.R184L	DO23822	LUAD	ICGC	PATTPNIS	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.2222
p.R178I	TCGA-D1-A17Q	UCEC	TCGA	PATTPNIS	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0556
p.R178I	DO41903	UCEC	ICGC	PATTPNIS	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.0556
p.K204N	TCGA-ER-A196	SKCM	TCGA	PATTPNIS	DEG_SCF_FBW7_1	188:195	Mutation substituting flanking lysine	0.1944
p.T191M	TCGA-FI-A2D0	UCEC	TCGA	PATTPNIS	DEG_SCF_FBW7_1	188:195	Mutation altering degron motif	0.8534
p.T191M	DO43891	UCEC	ICGC	PATTPNIS	DEG_SCF_FBW7_1	188:195	Mutation altering degron motif	0.8534
p.S195F	DO48444	BLCA	ICGC	PATTPNIS	DEG_SCF_FBW7_1	188:195	Mutation altering degron motif	0.9093
p.A189D	DO228985	LICA	ICGC	PATTPNIS	DEG_SCF_FBW7_1	188:195	Mutation altering degron motif	0.6682
p.N200S	DO232852	NACA	ICGC	PATTPNIS	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.1944
p.S187P	DO219881	SKCA	ICGC	PATTPNIS	DEG_SCF_FBW7_1	188:195	Mutation blocking phosphorylation signal	0.75
p.I184M	HCC2998	large intestine	COSMIC	PATTPNIS	DEG_SCF_FBW7_1	188:195	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons