DegronMD

Uniprot ID: P32519

Source protein: ETS-related transcription factor Elf-1

Source gene: ELF1

Class: DEG_SCF_FBW7_1

Location: 188:195

E3 ligase: FBXW7

DEGRON score: 0.8464

ASA_SCORE: 82.1875

COIL: 0.9046

CONS_SCORE: 0.4893

DSS_SCORE: 0.7292

HELIX: 0.0733

FCONS_SCORE: 0.9079

RIG_SCORE: 0.6457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R184L	TCGA-80-5611	LUAD	TCGA	PATTPNIS	DEG_SCF_FBW7_1	0.2222
p.R184L	DO23822	LUAD	ICGC	PATTPNIS	DEG_SCF_FBW7_1	0.2222
p.R178I	TCGA-D1-A17Q	UCEC	TCGA	PATTPNIS	DEG_SCF_FBW7_1	0.0556
p.R178I	DO41903	UCEC	ICGC	PATTPNIS	DEG_SCF_FBW7_1	0.0556
p.K204N	TCGA-ER-A196	SKCM	TCGA	PATTPNIS	DEG_SCF_FBW7_1	0.1944
p.T191M	TCGA-FI-A2D0	UCEC	TCGA	PATTPNIS	DEG_SCF_FBW7_1	0.8534
p.T191M	DO43891	UCEC	ICGC	PATTPNIS	DEG_SCF_FBW7_1	0.8534
p.S195F	DO48444	BLCA	ICGC	PATTPNIS	DEG_SCF_FBW7_1	0.9093
p.A189D	DO228985	LICA	ICGC	PATTPNIS	DEG_SCF_FBW7_1	0.6682
p.N200S	DO232852	NACA	ICGC	PATTPNIS	DEG_SCF_FBW7_1	0.1944
p.S187P	DO219881	SKCA	ICGC	PATTPNIS	DEG_SCF_FBW7_1	0.75
p.I184M	HCC2998	large_intestine	COSMIC	PATTPNIS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P32519	ETS-related transcription factor Elf-1	DEG_SCF_FBW7_1	188:195	PATTPNIS	FBXW7	0.8464	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons