DegronMD - P32969(RPL9; RPL9P7; RPL9P8; RPL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A164P	TCGA-61-2087	OV	TCGA	IRKFLDGIY	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1111
p.A164P	DO32039	OV	ICGC	IRKFLDGIY	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1111
p.L176V	TCGA-AN-A046	BRCA	TCGA	IRKFLDGIY	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.6765
p.L176V	DO1285	BRCA	ICGC	IRKFLDGIY	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.6765
p.R173M	TCGA-DZ-6133	KIRP	TCGA	IRKFLDGIY	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.8632
p.R173M	DO20762	KIRP	ICGC	IRKFLDGIY	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.8632
p.I179F	DO23138	LINC	ICGC	IRKFLDGIY	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.7415
p.Y180C	DO23138	LINC	ICGC	IRKFLDGIY	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.7087
p.K184Q	DO50776	LIRI	ICGC	IRKFLDGIY	DEG_APCC_DBOX_1	172:180	Mutation blocking ubiquitination signal	0.6667
p.K184E	SIDM01045	Endometrial Carcinoma	GDSC	IRKFLDGIY	DEG_APCC_DBOX_1	172:180	Mutation blocking ubiquitination signal	0.6667
p.K184E	ACH-000978	Endometrial/Uterine Cancer	CCLE	IRKFLDGIY	DEG_APCC_DBOX_1	172:180	Mutation blocking ubiquitination signal	0.6667
p.K184E	EN	endometrium	COSMIC	IRKFLDGIY	DEG_APCC_DBOX_1	172:180	Mutation blocking ubiquitination signal	0.6667
p.D178Y	ESS-1	endometrium	COSMIC	IRKFLDGIY	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.7325

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons