DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A164P	TCGA-61-2087	OV	TCGA	IRKFLDGIY	DEG_APCC_DBOX_1	0.1111
p.A164P	DO32039	OV	ICGC	IRKFLDGIY	DEG_APCC_DBOX_1	0.1111
p.L176V	TCGA-AN-A046	BRCA	TCGA	IRKFLDGIY	DEG_APCC_DBOX_1	0.6765
p.L176V	DO1285	BRCA	ICGC	IRKFLDGIY	DEG_APCC_DBOX_1	0.6765
p.R173M	TCGA-DZ-6133	KIRP	TCGA	IRKFLDGIY	DEG_APCC_DBOX_1	0.8632
p.R173M	DO20762	KIRP	ICGC	IRKFLDGIY	DEG_APCC_DBOX_1	0.8632
p.I179F	DO23138	LINC	ICGC	IRKFLDGIY	DEG_APCC_DBOX_1	0.7415
p.Y180C	DO23138	LINC	ICGC	IRKFLDGIY	DEG_APCC_DBOX_1	0.7087
p.K184Q	DO50776	LIRI	ICGC	IRKFLDGIY	DEG_APCC_DBOX_1	0.6667
p.K184E	SIDM01045	Endometrial Carcinoma	GDSC	IRKFLDGIY	DEG_APCC_DBOX_1	0.6667
p.K184E	ACH-000978	Endometrial/Uterine Cancer	CCLE	IRKFLDGIY	DEG_APCC_DBOX_1	0.6667
p.K184E	EN	endometrium	COSMIC	IRKFLDGIY	DEG_APCC_DBOX_1	0.6667
p.D178Y	ESS-1	endometrium	COSMIC	IRKFLDGIY	DEG_APCC_DBOX_1	0.7325

Drug responses associated with RPL9; RPL9P7; RPL9P8; RPL9P9 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50

All proteins holding degron of IRKFLDGIY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P32969	60S ribosomal protein L9	DEG_APCC_DBOX_1	172:180	IRKFLDGIY	APC,CDC20,FZR1	0.8732	More...