DegronMD - P33240(CSTF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R294W	TCGA-61-1900	OV	TCGA	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation rewiring degron network	0.0556
p.R294W	TCGA-AN-A0XL	BRCA	TCGA	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation rewiring degron network	0.0556
p.R294W	DO2395	BRCA	ICGC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation rewiring degron network	0.0556
p.R294W	DO32297	OV	ICGC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation rewiring degron network	0.0556
p.G268D	TCGA-AX-A0J1	UCEC	TCGA	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation rewiring degron network	0.2222
p.G268D	DO41199	UCEC	ICGC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation rewiring degron network	0.2222
p.G268V	TCGA-AX-A2HD	UCEC	TCGA	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation rewiring degron network	0.2222
p.G268V	DO42608	UCEC	ICGC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation rewiring degron network	0.2222
p.G275E	TCGA-D1-A17Q	UCEC	TCGA	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation altering degron motif	0.6087
p.G275E	DO41903	UCEC	ICGC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation altering degron motif	0.6087
p.G286E	TCGA-Z2-A8RT	SKCM	TCGA	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation rewiring degron network	0.2778
p.G286E	DO51301	SKCM	ICGC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation rewiring degron network	0.2778
p.P274S	DO222710	MELA	ICGC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation altering degron motif	0.6752
p.R294L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation rewiring degron network	0.0556
p.R294L	ACH-000951	Lung Cancer	CCLE	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation rewiring degron network	0.0556
p.R294L	NCI-H2342	lung	COSMIC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	272:284	Mutation rewiring degron network	0.0556

Kaplan plot for CSTF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSTF2

UniProt ID: P33240

Entrez ID: 1478

Protein name: Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CSTF2 in