DegronMD

Uniprot ID: P33240

Source protein: Cleavage stimulation factor subunit 2

Source gene: CSTF2

Class: DEG_ODPH_VHL_1

Location: 272:284

E3 ligase: VHL

DEGRON score: 0.9641

ASA_SCORE: 70.7231

COIL: 0.8898

CONS_SCORE: 0.3694

DSS_SCORE: 0.664

HELIX: 0.0642

FCONS_SCORE: 0.9944

RIG_SCORE: 0.5875

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R294W	TCGA-61-1900	OV	TCGA	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.0556
p.R294W	TCGA-AN-A0XL	BRCA	TCGA	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.0556
p.R294W	DO2395	BRCA	ICGC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.0556
p.R294W	DO32297	OV	ICGC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.0556
p.G268D	TCGA-AX-A0J1	UCEC	TCGA	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.2222
p.G268D	DO41199	UCEC	ICGC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.2222
p.G268V	TCGA-AX-A2HD	UCEC	TCGA	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.2222
p.G268V	DO42608	UCEC	ICGC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.2222
p.G275E	TCGA-D1-A17Q	UCEC	TCGA	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.6087
p.G275E	DO41903	UCEC	ICGC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.6087
p.G286E	TCGA-Z2-A8RT	SKCM	TCGA	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.2778
p.G286E	DO51301	SKCM	ICGC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.2778
p.P274S	DO222710	MELA	ICGC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.6752
p.R294L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.0556
p.R294L	ACH-000951	Lung Cancer	CCLE	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.0556
p.R294L	NCI-H2342	lung	COSMIC	LAPGGGMQAQVGM	DEG_ODPH_VHL_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33240	Cleavage stimulation factor subunit 2	DEG_ODPH_VHL_1	272:284	LAPGGGMQAQVGM	VHL	0.9641	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons