DegronMD - P34896(SHMT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R397W	TCGA-5P-A9KE	KIRP	TCGA	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.1667
p.R397W	TCGA-A5-A1OF	UCEC	TCGA	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.1667
p.A395V	TCGA-A5-A0GP	UCEC	TCGA	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.1111
p.R402W	TCGA-A6-6781	COAD	TCGA	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.3056
p.T409M	TCGA-AZ-6601	COAD	TCGA	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation altering degron motif	0.7423
p.L396V	TCGA-DK-A3WW	BLCA	TCGA	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.1389
p.L396V	TCGA-DR-A0ZM	CESC	TCGA	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.1389
p.A407S	TCGA-IB-7651	PAAD	TCGA	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation altering degron motif	0.6477
p.R411C	TCGA-J9-A52C	PRAD	TCGA	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.2778
p.L401P	TCGA-UZ-A9PZ	KIRP	TCGA	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.2778
p.D416Y	DO230334	COCA	ICGC	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation blocking ubiquitination signal	0.5833
p.D416Y	OCUB-M	breast	COSMIC	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation blocking ubiquitination signal	0.5833
p.D399N	DO20082	KIRC	ICGC	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.2222
p.D399N	DO229232	THCA	ICGC	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.2222
p.D399N	DO40884	UCEC	ICGC	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.2222
p.Q397R	DO229268	THCA	ICGC	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.1667
p.K410M	DO229275	THCA	ICGC	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.3056
p.L413F	SIDM00216	Colorectal Carcinoma	GDSC	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.2222
p.L413F	ACH-000989	Colon/Colorectal Cancer	CCLE	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.2222
p.L413F	SNU-175	large intestine	COSMIC	LGTPALT	DEG_SCF_FBW7_1	403:409	Mutation rewiring degron network	0.2222

Kaplan plot for SHMT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHMT1

UniProt ID: P34896

Entrez ID: 6470

Protein name: Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHMT1 in