DegronMD

Uniprot ID: P34896

Source protein: Serine hydroxymethyltransferase, cytosolic

Source gene: SHMT1

Class: DEG_SCF_FBW7_1

Location: 403:409

E3 ligase: FBXW7

DEGRON score: 0.751

ASA_SCORE: 21.0143

COIL: 0.5306

CONS_SCORE: 0.8043

DSS_SCORE: 0.3418

HELIX: 0.3507

FCONS_SCORE: 1.2534

RIG_SCORE: 0.7269

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T409M	TCGA-AZ-6601	COAD	TCGA	LGTPALT	DEG_SCF_FBW7_1	0.7423
p.A407S	TCGA-IB-7651	PAAD	TCGA	LGTPALT	DEG_SCF_FBW7_1	0.6477
p.D416Y	DO230334	COCA	ICGC	LGTPALT	DEG_SCF_FBW7_1	0.5833
p.D416Y	OCUB-M	breast	COSMIC	LGTPALT	DEG_SCF_FBW7_1	0.5833
p.R402W	TCGA-A6-6781	COAD	TCGA	LGTPALT	DEG_SCF_FBW7_1	0.3056
p.K410M	DO229275	THCA	ICGC	LGTPALT	DEG_SCF_FBW7_1	0.3056
p.R411C	TCGA-J9-A52C	PRAD	TCGA	LGTPALT	DEG_SCF_FBW7_1	0.2778
p.L401P	TCGA-UZ-A9PZ	KIRP	TCGA	LGTPALT	DEG_SCF_FBW7_1	0.2778
p.D399N	DO20082	KIRC	ICGC	LGTPALT	DEG_SCF_FBW7_1	0.2222
p.D399N	DO229232	THCA	ICGC	LGTPALT	DEG_SCF_FBW7_1	0.2222
p.D399N	DO40884	UCEC	ICGC	LGTPALT	DEG_SCF_FBW7_1	0.2222
p.L413F	SIDM00216	Colorectal Carcinoma	GDSC	LGTPALT	DEG_SCF_FBW7_1	0.2222
p.L413F	ACH-000989	Colon/Colorectal Cancer	CCLE	LGTPALT	DEG_SCF_FBW7_1	0.2222
p.L413F	SNU-175	large_intestine	COSMIC	LGTPALT	DEG_SCF_FBW7_1	0.2222
p.R397W	TCGA-5P-A9KE	KIRP	TCGA	LGTPALT	DEG_SCF_FBW7_1	0.1667
p.R397W	TCGA-A5-A1OF	UCEC	TCGA	LGTPALT	DEG_SCF_FBW7_1	0.1667
p.Q397R	DO229268	THCA	ICGC	LGTPALT	DEG_SCF_FBW7_1	0.1667
p.L396V	TCGA-DK-A3WW	BLCA	TCGA	LGTPALT	DEG_SCF_FBW7_1	0.1389
p.L396V	TCGA-DR-A0ZM	CESC	TCGA	LGTPALT	DEG_SCF_FBW7_1	0.1389
p.A395V	TCGA-A5-A0GP	UCEC	TCGA	LGTPALT	DEG_SCF_FBW7_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P34896	Serine hydroxymethyltransferase, cytosolic	DEG_SCF_FBW7_1	403:409	LGTPALT	FBXW7	0.751	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons