DegronMD - P34931(HSPA1L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L458Q	TCGA-44-A4SS	LUAD	TCGA	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.3056
p.L458Q	DO24227	LUAD	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.3056
p.L458Q	ACH-001960	Bile Duct Cancer	CCLE	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.3056
p.G465E	TCGA-A5-A0G2	UCEC	TCGA	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.6087
p.G465E	DO41235	UCEC	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.6087
p.T452I	TCGA-AA-3811	COAD	TCGA	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.1389
p.T452I	DO7962	COAD	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.1389
p.A469T	TCGA-EY-A215	UCEC	TCGA	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.2778
p.A469T	DO42665	UCEC	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.2778
p.G472R	TCGA-FW-A3R5	SKCM	TCGA	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.1944
p.G472R	DO37406	SKCM	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.1944
p.P467S	TCGA-W3-A824	SKCM	TCGA	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.5641
p.P467S	DO51271	SKCM	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.5641
p.P467S	SIDM00545	Melanoma	GDSC	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.5641
p.P467S	ACH-000987	Skin Cancer	CCLE	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.5641
p.P467S	Mewo	skin	COSMIC	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.5641
p.Q475E	TCGA-ZF-AA4X	BLCA	TCGA	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.1111
p.Q475E	DO219091	BLCA	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.1111
p.R449S	DO41217	UCEC	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.0556
p.Q475P	SIDM01951	Colorectal Carcinoma	GDSC	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.1111
p.A450V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.0833
p.A450V	ACH-002256	Leukemia	CCLE	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.0833
p.A450V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	GRFDLTGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.0833

Kaplan plot for HSPA1L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HSPA1L

UniProt ID: P34931

Entrez ID: 3305

Protein name: Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HSPA1L in