DegronMD

Uniprot ID: P34931

Source protein: Heat shock 70 kDa protein 1-like

Source gene: HSPA1L

Class: DEG_APCC_DBOX_1

Location: 459:467

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6253

ASA_SCORE: 49.0222

COIL: 0.5686

CONS_SCORE: 0.8951

DSS_SCORE: 0.3872

HELIX: 0.053

FCONS_SCORE: 0.97

RIG_SCORE: 0.7858

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G465E	TCGA-A5-A0G2	UCEC	TCGA	GRFDLTGIP	DEG_APCC_DBOX_1	0.6087
p.G465E	DO41235	UCEC	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	0.6087
p.P467S	TCGA-W3-A824	SKCM	TCGA	GRFDLTGIP	DEG_APCC_DBOX_1	0.5641
p.P467S	DO51271	SKCM	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	0.5641
p.P467S	SIDM00545	Melanoma	GDSC	GRFDLTGIP	DEG_APCC_DBOX_1	0.5641
p.P467S	ACH-000987	Skin Cancer	CCLE	GRFDLTGIP	DEG_APCC_DBOX_1	0.5641
p.P467S	Mewo	skin	COSMIC	GRFDLTGIP	DEG_APCC_DBOX_1	0.5641
p.L458Q	TCGA-44-A4SS	LUAD	TCGA	GRFDLTGIP	DEG_APCC_DBOX_1	0.3056
p.L458Q	DO24227	LUAD	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	0.3056
p.L458Q	ACH-001960	Bile Duct Cancer	CCLE	GRFDLTGIP	DEG_APCC_DBOX_1	0.3056
p.A469T	TCGA-EY-A215	UCEC	TCGA	GRFDLTGIP	DEG_APCC_DBOX_1	0.2778
p.A469T	DO42665	UCEC	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	0.2778
p.G472R	TCGA-FW-A3R5	SKCM	TCGA	GRFDLTGIP	DEG_APCC_DBOX_1	0.1944
p.G472R	DO37406	SKCM	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	0.1944
p.T452I	TCGA-AA-3811	COAD	TCGA	GRFDLTGIP	DEG_APCC_DBOX_1	0.1389
p.T452I	DO7962	COAD	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	0.1389
p.Q475E	TCGA-ZF-AA4X	BLCA	TCGA	GRFDLTGIP	DEG_APCC_DBOX_1	0.1111
p.Q475E	DO219091	BLCA	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	0.1111
p.Q475P	SIDM01951	Colorectal Carcinoma	GDSC	GRFDLTGIP	DEG_APCC_DBOX_1	0.1111
p.A450V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	GRFDLTGIP	DEG_APCC_DBOX_1	0.0833
p.A450V	ACH-002256	Leukemia	CCLE	GRFDLTGIP	DEG_APCC_DBOX_1	0.0833
p.A450V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	GRFDLTGIP	DEG_APCC_DBOX_1	0.0833
p.R449S	DO41217	UCEC	ICGC	GRFDLTGIP	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P34931	Heat shock 70 kDa protein 1-like	DEG_APCC_DBOX_1	459:467	GRFDLTGIP	APC,CDC20,FZR1	0.6253	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons