DegronMD - P34949(MPI)

FUNCTION: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

GO - Biological processes (BP): GDP-mannose biosynthetic process [GO:0009298]; mannose to fructose-6-phosphate metabolic process [GO:0061611]

GO - Molecular function (MF): mannose-6-phosphate isomerase activity [GO:0004476]; zinc ion binding [GO:0008270]

GO - Cellular component (CC): cytosol [GO:0005829]; extracellular exosome [GO:0070062]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S336L	TCGA-S5-AA26	BLCA	TCGA	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation altering degron motif	0.7667
p.S344L	DO480	BLCA	ICGC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation altering degron motif	0.7667
p.A339S	DO229032	LICA	ICGC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation altering degron motif	0.7588
p.D339G	TCGA-CM-5348	COAD	TCGA	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation altering degron motif	0.7198
p.N340S	IHH-4	thyroid	COSMIC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation altering degron motif	0.7069
p.V343F	DO228985	LICA	ICGC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation altering degron motif	0.7068
p.P337T	LNCaP-Clone-FGC	prostate	COSMIC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation altering degron motif	0.7031
p.G333V	DO229019	LICA	ICGC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation rewiring degron network	0.25
p.G332S	DO38214	STAD	ICGC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation rewiring degron network	0.2222
p.R331C	DO48687	LIRI	ICGC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation rewiring degron network	0.1944
p.P350L	DO43755	UCEC	ICGC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation rewiring degron network	0.1944
p.T350M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation rewiring degron network	0.1944
p.T350M	SIDM00614	Hepatocellular Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation rewiring degron network	0.1944
p.T350M	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation rewiring degron network	0.1944
p.T350M	SIDM00590	Oral Cavity Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation rewiring degron network	0.1944
p.T350M	SIDM00260	Gastric Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation rewiring degron network	0.1944
p.T350M	SIDM00363	Acute Myeloid Leukemia	GDSC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation rewiring degron network	0.1944
p.T350M	SIDM00302	Other Solid Cancers	GDSC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation rewiring degron network	0.1944
p.T350M	SIDM00243	Other Solid Cancers	GDSC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation rewiring degron network	0.1944
p.T350M	SIDM00359	Colorectal Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	336:345	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 33 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

MPI

UniProt ID: P34949

Entrez ID: 4351

Protein name: Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) (PMI)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MPI in