DegronMD

Uniprot ID: P34949

Source protein: Mannose-6-phosphate isomerase

Source gene: MPI

Class: DEG_COP1_1

Location: 336:345

E3 ligase: COP1

DEGRON score: 0.7321

ASA_SCORE: 43.68

COIL: 0.5879

CONS_SCORE: 0.5538

DSS_SCORE: 0.333

HELIX: 0.022

FCONS_SCORE: 1.2816

RIG_SCORE: 0.7799

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E351K	TCGA-AG-3726	READ	TCGA	SIYDPPVPDF	DEG_COP1_1	0.1667
p.V352I	TCGA-AP-A0LG	UCEC	TCGA	SIYDPPVPDF	DEG_COP1_1	0.1389
p.D339G	TCGA-CM-5348	COAD	TCGA	SIYDPPVPDF	DEG_COP1_1	0.7198
p.R328Q	TCGA-EE-A2MM	SKCM	TCGA	SIYDPPVPDF	DEG_COP1_1	0.1111
p.S336L	TCGA-S5-AA26	BLCA	TCGA	SIYDPPVPDF	DEG_COP1_1	0.7667
p.S344L	DO480	BLCA	ICGC	SIYDPPVPDF	DEG_COP1_1	0.7667
p.V343F	DO228985	LICA	ICGC	SIYDPPVPDF	DEG_COP1_1	0.7068
p.G333V	DO229019	LICA	ICGC	SIYDPPVPDF	DEG_COP1_1	0.25
p.A339S	DO229032	LICA	ICGC	SIYDPPVPDF	DEG_COP1_1	0.7588
p.R331C	DO48687	LIRI	ICGC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.G332S	DO38214	STAD	ICGC	SIYDPPVPDF	DEG_COP1_1	0.2222
p.P350L	DO43755	UCEC	ICGC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM00614	Hepatocellular Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM00590	Oral Cavity Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM00260	Gastric Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM00363	Acute Myeloid Leukemia	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM00302	Other Solid Cancers	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM00243	Other Solid Cancers	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM00359	Colorectal Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM01551	Gastric Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM00169	Head and Neck Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM00248	Gastric Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM01378	Ovarian Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM01451	Pancreatic Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM01756	Chronic Myelogenous Leukemia	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.T350M	SIDM01729	Endometrial Carcinoma	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1944
p.V352G	SIDM01217	Other Blood Cancers	GDSC	SIYDPPVPDF	DEG_COP1_1	0.1389
p.N340S	IHH-4	thyroid	COSMIC	SIYDPPVPDF	DEG_COP1_1	0.7069
p.P326T	LNCaP-Clone-FGC	prostate	COSMIC	SIYDPPVPDF	DEG_COP1_1	0.0556
p.P337T	LNCaP-Clone-FGC	prostate	COSMIC	SIYDPPVPDF	DEG_COP1_1	0.7031
p.N351S	IHH-4	thyroid	COSMIC	SIYDPPVPDF	DEG_COP1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SIYDPPVPDF

Degron related mutations and impact score

Drug responses associated with MPI mutations

All proteins holding degron of SIYDPPVPDF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P34949	Mannose-6-phosphate isomerase	DEG_COP1_1	336:345	SIYDPPVPDF	COP1	0.7321	More...